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首页> 外文期刊>Shock: Molecular, cellular, and systemic pathobiological aspects and therapeutic approaches = The official journal of the Shock Society, the European Shock Society, the Brazilian Shock Society, the International Federation of Shock Societies >Sex differences in the long-term outcome after a severe thermal injury.
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Sex differences in the long-term outcome after a severe thermal injury.

机译：性别差异在长期的结果严重的热损伤。

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摘要

We have recently shown that during the acute phase, postburn female pediatric burn patients had significantly increased levels of anabolic hormones with an associated decreased hypermetabolism leading to a significant shorter intensive care unit stay compared with male patients. The aim of the present study was to determine possible differences between girls and boys in body composition, hypermetabolism, and hormone pattern in the long term. Sixty-two children (1-16 years old) who sustained a severe thermal injury (>or=40% total body surface area) were included into the study. Patients were further divided into girls (n = 22) and boys (n = 40). Patient demographics, nutritional support, and mortality were noted. Resting energy expenditure (REE) was measured by indirect calorimetry, body composition by dual-energy x-ray absorptiometry (Hologic Inc, Waltham, Mass) at discharge, 3, 6, 9, 12, 18, and 24 months after burn. In addition, blood was drawn at the same time points, and serum hormones were measured. There were no significant differences between girls and boys for demographics, nutritional intake, or concomitant injuries. Predicted REE was significantly decreased in girls at discharge, 6, 12, and 18 months postburn (P < 0.05). Dual-energy x-ray absorptiometry scan showed that girls had improved change in bone mineral content and percent fat compared with boys (P < 0.05). There were no differences in changes in height, body weight, lean body mass, and total fat between groups. Girls had significantly higher levels of insulinlike growth factor 1, insulinlike growth factor binding protein 3, free thyroxine index, T4, and insulin when compared with boys (P < 0.05). No differences were found for T3 uptake, osteocalcin, cortisol, growth hormone, and parathyroid hormone (PTH) between groups. Data indicate that girls have a reduced REE associated with changes in bone content and endogenous anabolic hormones.
机译：我们最近发现,在急性阶段,postburn女性小儿烧伤病人水平有了显著提高合成激素的减少有关代谢亢进导致显著的短重症监护室保持与男性相比病人。确定可能的女孩和之间的区别男孩在身体成分、代谢亢进和激素模式从长远来看。(1 - 16岁的儿童)持续的严重热损伤(> = 40%体表面积)被列入研究。进一步划分为男孩和女孩(n = 22) (n =40)。和死亡率。支出(REE)被间接测量量热法,通过双能身体成分x线吸收仪(Hologic Inc .,沃尔瑟姆,质量)在放电,3、6、9、12、18、24个月后燃烧。同样的时间点,和血清激素测量。男孩和女孩之间的人口统计数据,营养摄入,或伴随的损伤。预测REE明显减少女孩在放电,6、12和18个月postburn(P < 0.05)。显示,女孩已经改善骨的变化矿物含量和脂肪百分比相比男孩(P < 0.05)。高度的变化,体重,瘦体重,和脂肪之间的组织。的水平明显高于insulinlike增长因子1,insulinlike生长因子绑定蛋白质3、游离甲状腺素指数、T4和胰岛素与男孩相比(P < 0.05)。为T3吸收差异被发现,骨钙素、皮质醇、生长激素和甲状旁腺素组之间。表明,女孩有一个减少稀土元素相关的与骨内容和内生的变化合成代谢激素。

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