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首页> 外文期刊>Shock: Molecular, cellular, and systemic pathobiological aspects and therapeutic approaches = The official journal of the Shock Society, the European Shock Society, the Brazilian Shock Society, the International Federation of Shock Societies >Single bolus injection of bilirubin improves the clinical outcome in a mouse model of endotoxemia.
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Single bolus injection of bilirubin improves the clinical outcome in a mouse model of endotoxemia.

机译：单丸注入胆红素改善内毒素的临床结果在小鼠模型。

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摘要

Increasing serum levels of biliverdin and bilirubin was shown to be beneficial in settings of inflammation. Bilirubin was shown to be protective in LPS-induced lung injury in rats; however, the exact mechanism remains elusive. Here, we investigated whether a single bolus injection of bilirubin would exert anti-inflammatory effects in a mouse model of endotoxemia. Mice were challenged with sublethal doses (2 mg/kg body weight) of LPS, and the effects of intravenously administered bilirubin (40 mg/kg body weight) were assessed. In contrast to control animals, bilirubin-treated animals fully recovered from endotoxin shock within 24 h. Bilirubin treatment improved the clinical score significantly at all time points assessed, attenuated weight loss, and improved LPS-induced anorexia. Furthermore, bilirubin treatment inhibited LPS-induced leukocyte-endothelial interactions and leukocyte accumulation in various tissues. Expression of inflammatory genes, including endothelial adhesion molecules, but also IL-1beta and TNF-alpha, was significantly reduced in bilirubin-treated animals. Moreover, bilirubin inhibited LPS-induced expression of inflammatory genes in isolated cultured aortic endothelial cells and in bone marrow-derived macrophages. These data show that single-dose administration of bilirubin attenuates tissue injury induced by endotoxin, and that bilirubin, in addition to its antioxidant effects, also exerts potent anti-inflammatory activity.
机译：血清胆绿素水平和增加在设置胆红素被证明是有益的的炎症。保护在LPS-induced在大鼠肺损伤;然而,确切的机制仍然是难以捉摸的。在这里,我们调查是否单个丸注入胆红素会发挥抗炎小鼠模型的影响内毒素。剂量(2毫克/公斤体重)有限合伙人,和静脉注射胆红素的影响(40毫克/公斤体重)进行评估。控制动物,bilirubin-treated动物24小时内完全恢复从内毒素休克。胆红素处理提高了临床评分大大在所有时间点进行评估,减减肥,改善LPS-induced厌食症。抑制LPS-induced leukocyte-endothelial交互和白细胞在积累各种组织。基因,包括内皮细胞粘附分子,而且IL-1beta和tnf在bilirubin-treated显著降低动物。LPS-induced炎症基因的表达孤立的主动脉内皮细胞和培养骨骨髓来源的巨噬细胞。单剂量的胆红素变弱内毒素引起的组织损伤,胆红素,除了它抗氧化效果,也施加强有力的抗炎活性。

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