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首页> 外文期刊>Shock: Molecular, cellular, and systemic pathobiological aspects and therapeutic approaches = The official journal of the Shock Society, the European Shock Society, the Brazilian Shock Society, the International Federation of Shock Societies >Intrapulmonary delivery of ethyl pyruvate attenuates lipopolysaccharide- and lipoteichoic acid-induced lung inflammation in vivo.
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Intrapulmonary delivery of ethyl pyruvate attenuates lipopolysaccharide- and lipoteichoic acid-induced lung inflammation in vivo.

机译：肺内的丙酮酸乙酯减弱脂多糖和lipoteichoic段时间肺部炎症体内。

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摘要

Ethyl pyruvate (EP) is a stable pyruvate derivative that has been shown to exert anti-inflammatory effects in various models of systemic inflammation including endotoxemia. We here sought to determine the local effects of EP, after intrapulmonary delivery, in models of lung inflammation induced by instillation via the airways of either lipopolysaccharide (LPS, a constituent of the gram-negative bacterial cell wall) or lipoteichoic acid (LTA, a component of the gram-positive bacterial cell wall). For this, we first established that EP dose dependently reduced the responsiveness of mouse MH-S alveolar macrophages and mouse MLE-15 and MLE-12 respiratory epithelial cells to stimulation with LPS or LTA in vitro. We then showed that intranasal administration of EP dose dependently inhibited tumor necrosis factor alpha release in bronchoalveolar lavage fluid of mice challenged with either LPS or LTA via the airways. Moreover, EP reduced the recruitment of neutrophils into the bronchoalveolar space after either LPS or LTA administration. These data suggest that intrapulmonary delivery of EP diminishes lung inflammation induced by LPS or LTA, at least in part by targeting alveolar macrophages and respiratory epithelial cells.
机译：丙酮酸乙酯(EP)是一个稳定的丙酮酸导数可以发挥各模型的抗炎作用系统性炎症包括内毒素。这里试图确定EP的局部效应,肺内的交付后,模型的肺滴注法通过引起的炎症航空公司的脂多糖(LPS革兰氏阴性细菌细胞的成分(LTA,墙)或lipoteichoic酸的一个组成部分革兰氏阳性细菌细胞壁)。我们首先建立了EP剂量依赖性减少了鼠标MH-S肺泡的响应能力巨噬细胞和老鼠MLE-15 MLE-12呼吸道上皮细胞的刺激有限合伙人或LTA体外。鼻内EP剂量依赖性抑制肿瘤坏死因子α版本小鼠支气管肺泡灌洗液的挑战通过航空公司与有限合伙人或本公司。EP招募中性粒细胞减少有限合伙人或LTA后支气管肺泡空间管理。肺内的交付EP减少肺炎症引起的有限合伙人或本公司,至少在通过针对肺泡巨噬细胞和部分呼吸道上皮细胞。

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