Ticagrelor versus clopidogrel in patients with acute coronary syndromes intended for non-invasive management: substudy from prospective randomised PLATelet inhibition and patient Outcomes (PLATO) trial

Stefan K James; Matthew T Roe; Christopher P CannonJan H CornelJay HorrowSteen HustedHugo KatusJoao MoraisPh Gabriel StegRobert F StoreySusanna StevensLars WallentinRobert A Harrington2 for the PLATO Study Group

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Ticagrelor versus clopidogrel in patients with acute coronary syndromes intended for non-invasive management: substudy from prospective randomised PLATelet inhibition and patient Outcomes (PLATO) trial

机译：Ticagrelor与氯吡格雷的患者急性冠脉综合征的目的非侵入性的管理:substudy前瞻性随机和血小板抑制率病人(柏拉图)试验结果

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STUDY QUESTION What was the randomised outcome of the 5216 patients who were specified as planned for non-invasive management in the PLATO trial? SUMMARY ANSWER In patients with acute coronary syndrome who were initially intended for non-invasive management, the benefits of ticagrelor over clopidogrel were consistent with those from the overall PLATO results. WHAT IS KNOWN AND WHATTHIS PAPER ADDS Half of all patients admitted with non-ST elevation acute coronary syndrome in the Western world do not initially have revascularisation treatment, in patients initially intended for non-invasive management, ticagrelor caused a clinically important reduction in ischaemic events and mortality without increasing major bleeding compared with clopidogrel, so the benefits of intensified P2Y12 inhibition apply across different management strategies.

机译：研究问题的随机的结果是什么按原计划指定的5216名患者非侵入性管理在柏拉图的审判吗?总结回答患者的急性冠状最初用于综合症非侵入式管理的好处ticagrelor氯吡格雷是一致的柏拉图的整体结果。是已知的和滥交论文增加了一半患者承认non-ST海拔急性冠脉综合征在西方世界最初有血管形成治疗患者最初用于非侵入性管理、ticagrelor引起了临床减少缺血性事件和重要主要出血死亡率没有增加与氯吡格雷相比,这样的好处加强P2Y12抑制应用不同的管理策略。

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来源
《BMJ: British medical journal》 |2011年第7812期|1403-1403|共1页
作者
Stefan K James; Matthew T Roe; Christopher P CannonJan H CornelJay HorrowSteen HustedHugo KatusJoao MoraisPh Gabriel StegRobert F StoreySusanna StevensLars WallentinRobert A Harrington2 for the PLATO Study Group;
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作者单位

Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden;

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原文格式 PDF
正文语种英语
中图分类医药、卫生;
关键词
clopidogrel; Ticagrelor; PatientsWestern WorldAcute Coronary Syndrome;

机译：氯吡格雷;Ticagrelor PatientsWestern WorldAcute冠状动脉综合症;

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Ticagrelor versus clopidogrel in patients with acute coronary syndromes intended for non-invasive management: substudy from prospective randomised PLATelet inhibition and patient Outcomes (PLATO) trial

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