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首页> 外文期刊>BMJ: British medical journal >Panvax febrile reactions not a predictor
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Panvax febrile reactions not a predictor

机译：不是一个预测Panvax发热反应

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摘要

Collignon and colleagues assert that febrile reactions seen in pandemic influenza A/ H1N1 vaccine (Panvax) clinical trials were an overlooked predictor of the excess febrile reactions seen with CSL's seasonal trivalent influenza vaccine that prompted suspension of its use in children under 5.1 Yet most febrile reactions reported in the Australian Panvax trial were mild, with severe fever (>39.5癈) in only 2%.2 Fever was dose related, and the results included children who received 30 ug-four times the dose in Fluvaxjunior. In the 15 ug arm, only one child had severe fever after the first dose. In the US trial,3 which evaluated 7.5 ug and 15 ug doses, rates of moderate and severe fever in under 3s in the 7.5 ug arm were both less than 2%. In children 3 years and older, rates of fever in the 7.5 ug group were similar to those for placebo. Severe fever did not occur.
机译：Collignon和同事断言发热反应在大流行性流感A / H1N1疫苗(Panvax)是一个临床试验忽视了过度发热性预测反应了CSL的季节性三价流感疫苗促使暂停它在5.1以下儿童使用大多数发热反应在澳大利亚Panvax试验报告轻微,严重的发烧(> 39.5癈)2%。2包括孩子收到30 ug-four乘以Fluvaxjunior的剂量。一个孩子有严重的发烧后第一个剂量。在美国审判,3评估7.5 ug和15ug剂量,中度和重度发烧下3 s在7.5 ug的手臂都不到2%。在7.5 ug组类似安慰剂。

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