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首页> 外文期刊>BMJ: British medical journal >Ontological fallacy in heart failure
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Ontological fallacy in heart failure

机译:本体论谬论在心力衰竭

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Echocardiography has resulted in the belief that heart failure and reduced ejection fraction are synonymous. Recently, however, the utility of ejection fraction in diagnosis has been undermined by epidemiological studies, which have shown that ejgction fraction is continuously distributed in populations with heart failure, and that survival is the same irrespective of whether there is heart failure with normal ejection fraction (HFNEF) or with reduced ejection fraction (HFREF). In effect it is the clinical label of heart failure that drives prognosis, not the ejection fraction. The adoption of a dichotomous value (the division of cardiac function into normal and reduced ejection fraction) to describe a continuous variable is now outmoded and unhelpful. The relative lack of benefit in studies in HFNEF-may be a failure of the therapeutic modes of action of the drugs studied, since there is no physiological reason why afterload reduction in non-dilated hearts will produce prognostic benefit. We may be trying the wrong drugs because we do not fully understand the condition. We do not understand the condition because ourterms of reference are those of echocardiography.
机译:超声心动图导致的信念心力衰竭和射血分数降低同义词。射血分数在诊断受到流行病学研究,表明ejgction分数不断分布在人口与心力衰竭,生存,无论相同是否有与正常心脏衰竭射血分数(HFNEF)或减少射血分数(HFREF)。临床的心脏衰竭驱动器预后,而不是射血分数。采用二分(分工的价值心脏功能正常,减少射血分数)来描述一个连续变量现在过时的和无益的。HFNEF-may效益研究的失败药物的治疗模式的行动研究,由于没有生理上的原因为什么后负荷减少non-dilated心将产生预后有益。因为我们并不完全错误的药物了解情况。因为参考ourterms状况超声心动图。

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