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首页> 外文期刊>BMJ: British medical journal >Neonatal vitamin A supplementation for prevention of mortality and morbidity in infancy: systematic review of randomised controlled trials
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Neonatal vitamin A supplementation for prevention of mortality and morbidity in infancy: systematic review of randomised controlled trials

机译：为预防新生儿维生素A补充婴儿的死亡率和发病率:系统的随机对照试验

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Objective To evaluate the effect of neonatal vitamin A supplementation on infant mortality, morbidity and early adverse effects.Design Systematic review, meta-analysis, and meta-regression of randomised controlled trials. Data sources Electronic databases and hand search of reviews; abstracts and proceedings of conferences. Review methods Randomised or quasi-randomised or cluster randomised, placebo controlled trials evaluating the effect of prophylactic, neonatal (<1 month) supplementation with synthetic vitamin A on mortality or morbidity within infancy (<1 year), and early adverse effects (27 days). Results The six included trials were from developing countries. There was no convincing evidence of a reduced risk of mortality during infancy (relative risk 0.92, 95% confidence interval 0.75 to 1.12, P=0.393 random effect; I~2=54.1%) or of an increase in early adverse effects indudingbulgingfontanelle (1.16,0.81 to 1.65, P=0.418; I~2=65.3%). No variable emerged as a significant predictor of mortality, but data for important risk groups (high maternal night blindness prevalence and low birth weights) were restricted. Limited data (from one to four trials) did not indicate a reduced risk of mortality during the neonatal period (0.90,0.75 to 1.08, P=0.270; P=0%), cause specific mortality, common morbidities (diarrhoea and others), and admission to hospital. There was, however, evidence of an increased risk of acute respiratory infection and a reduced risk of clinic visits. Conclusions There is no convincingevidence of a reduced risk of mortality and possibly morbidity or of increased early adverse effects after neonatal supplementation with vitamin A. There is thus no justification for initiating such supplementation as a public health intervention in developing countries for reducing infant mortality and morbidity.
机译：目的探讨新生儿的影响维生素A补充对婴儿死亡率,发病率和早期的不利影响。系统回顾、分析和多元回归的随机对照试验。数据源电子数据库和搜索评论;会议。quasi-randomised或集群随机,安慰剂对照试验评估的影响预防新生儿(< 1个月)的补充死亡率或合成维生素A发病率在婴儿期(< 1年),和早期不良反应(27天)。包括试验来自发展中国家。没有令人信服的证据的减少死亡率在婴儿期(相对风险的风险0.92, 95%置信区间0.75 - 1.12,P = 0.393随机效果;早期的不利影响indudingbulgingfontanelle (1.16, 0.81, 1.65,P = 0.418;重要的预测死亡率,但数据重要的风险组(高孕产妇的夜晚盲目患病率和低出生体重)限制。试验)没有显示减少的风险死亡率在新生儿期(0.90、0.751.08, P = 0.270;死亡率、常见精神障碍(腹泻和其他人),进入医院。然而,严重的风险增加的证据呼吸道感染的风险降低诊所访问。convincingevidence降低死亡的风险和可能的发病率或增加的早期新生儿补充后的不利影响与维生素a。因此没有理由为启动公共等补充发展中国家的卫生干预措施降低婴儿死亡率和发病率。

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