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首页> 外文期刊>BMJ: British medical journal >Trends in Down's syndrome live births and antenatal diagnoses in England and Wales from 1989 to 2008: analysis of data from the National Down Syndrome Cytogenetic Register
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Trends in Down's syndrome live births and antenatal diagnoses in England and Wales from 1989 to 2008: analysis of data from the National Down Syndrome Cytogenetic Register

机译:唐氏综合症出生和生活的趋势在英格兰和威尔士的产前诊断1989年至2008年:从国家的分析数据唐氏综合症细胞生成的注册

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摘要

The figure compares total numbers of Down's syndrome diagnoses (top line, rising from 1075 in 1989/90 to 1843 in 2007/8) with estimated numbers of Down's syndrome live births that would have occurred in the absence of antenatal diagnoses and selective termination (middle line, rising from 959 in 1989/90 to 1422 in 2007/8). The two lines differ because the top line includes pregnancies detected antenatally and terminated that, had the pregnancy continued, would have miscarried naturally and not resulted in a live birth. The bottom line shows estimated numbers of live born babies with Down's syndrome in the presence of antenatal diagnoses and selective termination (falling from 752 to 743, 1.10 to 1.08 per 1000 births). The difference between the bottom two lines is attributable to antenatal screening and subsequent terminations, the effects of which have clearly increased over time. The rise in the number of live births expected in the absence of screening and subsequent terminations is due to a true increase in the incidence of Down's syndrome, which can be attributed to the increase in maternal age.
机译:唐氏的图比较总数综合征诊断(顶线,从1075年的增长1989/90到1843年的2007/8),估计数字会的唐氏综合症婴儿安全出生发生在缺乏产前诊断和选择性终止(中线上升从959年的1989/90到1422年的2007/8)。行不同,因为包括第一线怀孕检测产前和终止,继续怀孕,会自然流产而导致生活出生。生活与唐氏综合症婴儿出生的产前诊断和选择性终止(从752年到743年,下降1.101000年的1.08‰)。下面两行是归因于产前筛查和随后的终端,的影响已明显增加时间。预计在缺乏筛查和随后终止是由于真正的提高在唐氏综合征的发生率归功于母亲的年龄的增加。

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