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首页> 外文期刊>BMJ: British medical journal >Perinatal mortality and other severe adverse pregnancy outcomes associated with treatment of cervical intraepithelial neoplasia: meta-analysis
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Perinatal mortality and other severe adverse pregnancy outcomes associated with treatment of cervical intraepithelial neoplasia: meta-analysis

机译：围产期死亡率和其他严重不良妊娠结局与治疗有关宫颈上皮内瘤:荟萃分析

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Objective To assess the relative risk of perinatal mortality, severe preterm delivery, and low birth weight associated with previous treatment for precursors of cervical cancer. Data sources Medline and Embase citation tracking from January 1960 to December 2007.Selection criteria Eligible studies had data on severe pregnancy outcomes for women with and without previous treatment for cervical intraepithelial neoplasia. Considered outcomes were perinatal mortality, severe preterm delivery (<32/34 weeks), extreme preterm delivery (<28/30 weeks), and low birth weight (<2000 g, <1500 g, and <1000 g). Excisional and ablative treatment procedures were distinguished.Results One prospective cohort and 19 retrospective studies were retrieved. Cold knife conisation was associated with a significantly increased risk of perinatal mortality (relative risk 2.87,95% confidence interval 1.42 to 5.81) and a significantly higher risk of severe preterm delivery (2.78,1.72 to 4.51), extreme preterm delivery (5.33,1.63 to 17.40), and low birth weight of <2000 g (2.86,1.37 to 5.97). Laser conisation, described in only one study, was also followed by a significantly increased chance of low birth weight of <2000 g and <1500 g. Large loop excision of the transformation zone and ablative treatment with cryotherapy or laser were not associated with a significantly increased risk of serious adverse pregnancy outcomes. Ablation by radical diathermy was associated with a significantly higher frequency of perinatal mortality, severe and extreme preterm delivery, and low birth weight below 2000 g or 1500g.
机译：摘要目的评估围产期的相对风险死亡率,严重早产和低出生重量与先前的治疗有关宫颈癌的前兆。从1月Medline和Embase引文跟踪1960年到2007年12月。研究数据严重的妊娠结局的女性,没有以前的治疗宫颈上皮内瘤。结果是围产期死亡率,严重的早产交付(< 32/34周),极端的早产(< 28/30周),低出生体重(< 2000克,< 1500 g, < 1000克),切除和烧蚀治疗过程是杰出的。一个前瞻性群组和19的回顾研究检索。关联到一个明显的风险增加围产期死亡率(相对危险度2.87,95%置信区间1.42 - 5.81)和一个明显高于严重早产的风险交付(2.78,1.72,4.51),极端的早产交付(5.33,1.63,17.40),和低出生的重量< 2000 g(2.86, 1.37, 5.97)。conisation,在只有一个研究中,描述也其次是显著增加的机会低出生体重的<和< 1500克2000克。循环转换区和切除烧蚀冷冻疗法或激光治疗没有显著增加严重不良妊娠结局的风险。通过激进的透热疗法与消融一个显著提高围产期的频率死亡率,严重和极度早产,与低出生体重低于2000克或1500克。

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