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首页> 外文期刊>BMJ: British medical journal >Commentary: Why stop at antidepressants?
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Commentary: Why stop at antidepressants?

机译：评论:为什么停在抗抑郁药?

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Two problems arise when assessing treatments for depression. The first is specific to depression and the second is inherent in using randomised controlled trials as the sole evidence for deciding questions about treatment. Moncrieff and Kirsch focus on drug treatments, yet most of these issues also apply to non-drug interventions.Parker has described the problems of a "one size fits all" approach to trials of treatment for depression in which people with different severities of illness and symptoms are all included under the same heading of depression.2 Ensuring participants remain blind to treatment is also a problem. Outcomes in depression trials are usually assessed with a rating scale. However, all rating scales are ordinal-someone who scores 20 on the Hamilton rating scale for depression is more depressed than someone who scores 10, but we can't say they are twice as depressed. Nevertheless, most researchers have assumed that you can, making the results (such as changes in mean scores) hard to interpret. Lastly, most trials of depression are for short periods. In the National Institute for Health and Clinical Excellence guidelines eight weeks is the cut-off for dividing trials into short term and long term studies.
机译：评估治疗时出现的两个问题抑郁症。使用随机和第二个是固有的对照试验的唯一证据决定关于待遇的问题。Kirsch关注药物治疗,但大多数这些问题也适用于非药物干预措施。“一刀切”的试验方法治疗抑郁症的人不同的疾病和症状的严重性包括相同的标题下depression.2治疗也是一个问题。抑郁症临床试验通常与评估评定量表。在汉密尔顿ordinal-someone得分20抑郁评定量表更沮丧比得分10人,但我们不能说他们抑郁的几率是一般人的两倍。研究人员认为,可以使结果(例如平均分数)的变化很难解释。在短时间内。八个健康和临床指导方针周是将实验分成的截止短期和长期的研究。

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