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首页> 外文期刊>BMJ: British medical journal >Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study
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Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study

机译：过去暴露于太阳,皮肤显型和风险多发性硬化:病例对照研究

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Objective To examine whether past high sun exposure is associated with a reduced risk of multiple sclerosis. Design Population based case-control study. Setting Tasmania, latitudes 41-3°S. Participants 136 cases with multiple sclerosis and 272 controls randomly drawn from the community and matched on sex and year of birth. Main outcome measure Multiple sclerosis defined by both clinical and magnetic resonance imaging criteria. Results Higher sun exposure when aged 6-15 years (average 2-3 hours or more a day in summer during weekends and holidays) was associated with a decreased risk of multiple sclerosis (adjusted odds ratio 0.31, 95% confidence interval 0.16 to 0.59). Higher exposure in winter seemed more important than higher exposure in summer. Greater actinic damage was also independently associated with a decreased risk of multiple sclerosis (0.32, 0.11 to 0.88 for grades 4-6 disease). A dose-response relation was observed between multiple sclerosis and decreasing sun exposure when aged 6-15 years and with actinic damage. Conclusion Higher sun exposure during childhood and early adolescence is associated with a reduced risk of multiple sclerosis. Insufficient ultraviolet radiation may therefore influence the development of multiple sclerosis.
机译：目的检查是否过去高的太阳暴露的风险降低相关多发性硬化症。病例对照研究。41-3°S。硬化和272名对照随机来自社区和匹配性和年出生。定义为临床和磁共振成像条件。当6 - 15岁(平均2 - 3小时或更多天在周末和假期)是在夏天与多个的风险降低有关硬化(调整后的优势比为0.31,95%置信区间0.16 - 0.59)。暴露在冬天似乎更重要更高的曝光在夏天。也被关联到一个独立减少风险的多发性硬化症(0.32、0.110.88的成绩4 - 6疾病)。多发性硬化症之间关系的观察6 - 15岁时和减少阳光照射与光化性损伤。早期暴露在儿童和青少年是多个风险减少硬化。因此影响多个的发展硬化。

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