Elucidating the pathogenesis of schizophrenia

Akira Sawa; Atsushi Kamiya

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Elucidating the pathogenesis of schizophrenia

机译：阐明精神分裂症的发病机理

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Genetic predisposition to schizophrenia is evident from family, twin, and adoption studies. But whereas genetic factors contribute to the fundamental mechanisms or vulnerability to schizophrenia, additional influences including environmental factors are clearly involved in the full manifestation of symptoms of schizophrenia. Thus currently schizophrenia is best conceptualised as a "multiple hit" illness similar to cancer. This editorial looks at the fundamental mechanisms underlying the disease. The following evidence implies that neurodevelop-mental abnormalities contribute to susceptibility to schizophrenia. Firstly, clinical studies show that patients with schizophrenia manifest minor behavioural abnormalities in childhood even before the onset of schizophrenia.

机译：精神分裂症遗传素质是显而易见的从家庭,双胞胎,和采用的研究。而遗传因素导致基本的机制或脆弱性包括精神分裂症、额外的影响环境因素显然是参与充分体现精神分裂症的症状。因此目前精神分裂症是最好的概念化作为“多个”疾病类似于癌症。基本机制。下列证据暗示neurodevelop-mental异常导致对精神分裂症的易感性。临床研究表明,患者精神分裂症的表现轻微的行为异常儿童甚至在开始之前精神分裂症的。

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来源
《BMJ: British medical journal》 |2003年第7416期|632-633|共2页
作者
Akira Sawa; Atsushi Kamiya;
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作者单位

Cellular Neurobiology Laboratory, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 2-181, Baltimore, MD 21287, USA;

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原文格式 PDF
正文语种英语
中图分类医药、卫生;
关键词
Genetic factors; Genetic Predisposition to Disease; pathogenesisVulnerabilitybasic mechanismSchizophrenia;

机译：遗传因素,遗传易感性疾病;pathogenesisVulnerabilitybasicmechanismSchizophrenia;

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Elucidating the pathogenesis of schizophrenia

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