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首页> 外文期刊>Applied in vitro toxicology. >Nootkatone Essential Oil-Encapsulated Lipid Nanoparticles Interaction with Rat Cardiomyoblast (H9c2) Cells
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Nootkatone Essential Oil-Encapsulated Lipid Nanoparticles Interaction with Rat Cardiomyoblast (H9c2) Cells

机译：Nootkatone基本Oil-Encapsulated脂质纳米颗粒与鼠Cardiomyoblast交互(H9c2)细胞

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Introduction: This study aimed to develop biocompatible lipid-mediated nootkatone (NK) essential oil-loaded solid lipid nanoparticles (SLNs) using Gelucire? 44/14 and to evaluate their interaction with rat cardiomyoblast (H9c2) cells.Methods: Solid lipid-mediated NK essential oil-loaded SLNs were prepared using an ethanol injection technique, and the proper exploration of various physicochemical characteristics and cellular investigations was systematically performed. The particle size, polydispersity index, zeta potential, drug loading, entrapment efficiency, in vitro drug release, cellular uptake, stability, and cytotoxicity were evaluated, and the hemolytic effects were studied.Results: The prepared SLNs were found to be in the nano-size range Conclusion: Hence, it can be concluded that solid lipid-mediated NK essential-oil-loaded SLNs enhanced the stability, safety, and potency of NK, and it may be a promising approach for the prevention and treatment of cardiovascular diseases. It can be further explored in preclinical and clinical settings to evaluate its mechanism of action.
机译：作品简介:本研究旨在发展生物相容性lipid-mediated nootkatone (NK)基本oil-loaded固体脂质纳米粒(sln)使用Gelucire ?他们的交互与鼠cardiomyoblast (H9c2)细胞。oil-loaded sln准备使用乙醇注入技术,和适当的探索各种物理化学特性和细胞调查系统执行。指数、电动电势、药物加载,截留效率,体外药物释放、细胞吸收、稳定性和细胞毒性评估和溶血的影响研究。在纳米范围的结论:因此,它可以得出的结论是,固体lipid-mediated NK吗essential-oil-loaded sln增强稳定性,NK的安全性和效力,它可能是一个预防和有前途的方法治疗心血管疾病。进一步在临床前和临床研究设置评价其作用机理。

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