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首页> 外文期刊>Journal of the peripheral nervous system : >Prediction of disease progression in Miller Fisher and?overlap syndromes
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Prediction of disease progression in Miller Fisher and?overlap syndromes

机译：预测疾病进展的米勒费雪和?

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Abstract Patients with Miller Fisher syndrome (MFS) may have a relatively mild clinical course or progress to Guillain‐Barré syndrome (GBS) with limb weakness (MFS‐GBS overlap syndrome). Other variants in this spectrum are GBS with ophthalmoparesis and Bickerstaff's Brainstem encephalitis (BBE). To compare the clinical course of MFS and overlap syndromes and to identify predictors of disease progression. In a prospective study of 170 patients with GBS and variant forms, 37 (22%) had a MFS, MFS‐GBS overlap syndrome, ophthalmoplegic GBS or BBE. The clinical, serological, and electrophysiological features were compared. Twenty‐three patients presented with MFS, of which 10 (43%) developed limb weakness (MFS‐GBS overlap syndrome). All these transitions occurred in the first week after onset of symptoms. There were no differences in the clinical, electrophysiological and serological features at entry between MFS and MFS‐GBS. Twelve patients had ophthalmoplegic GBS and the disease severity at nadir and outcome was worse than in the patients with a MFS‐GBS overlap syndrome. No early predictors for progression from MFS to MFS‐GBS overlap syndrome were found. All transitions occurred in the first week. This finding implicates that all patients with MFS need careful monitoring for at least 1 week.
机译：抽象的米勒费雪症候群患者(MFS)可能有一个相对温和的临床过程或者进步Guillain巴雷综合征(GBS)肢体软弱(MFS GBS应承担的重叠综合征)。在这个光谱变异GBSophthalmoparesis Bickerstaff脑干脑炎(终于)。MFS和重叠综合征识别疾病进展的预测因子。170 GBS患者的前瞻性研究变体形式,37例(22%)有一个MFS, MFS GBS重叠综合征,ophthalmoplegic GBS或好些。临床、血清学和电生理特性比较。面对MFS,其中10 (43%)肢体软弱(MFS GBS应承担的重叠综合征)。这些转变发生在第一周后出现症状。不同的临床、电生理学并在入口MFS和血清学特性MFS GBS。和疾病严重程度的最低点和结果比在一个MFS GBS患者重叠并发症状从MFS MFS GBS重叠综合症被发现。所有转换发生在第一周。发现涉及所有MFS患者需要仔细监测至少1周。

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