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首页> 外文期刊>Biology of Reproduction: Offical Journal of the Society for the Study of Reproduction >Changes in lipids containing long- and very long-chain polyunsaturated Fatty acids in cryptorchid rat testes.
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Changes in lipids containing long- and very long-chain polyunsaturated Fatty acids in cryptorchid rat testes.

机译：包含长,脂类的变化长链多不饱和脂肪酸患隐睾病的人鼠睾丸。

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摘要

The aim of the present study was to examine the effects of experimental cryptorchidism on rat testicular phospholipids and neutral lipids that contain long-chain (C(18)-C(22)) and very long-chain (VLC) (C(24)-C(32)) polyunsaturated fatty acids (PUFA). The weight of the cryptorchid testis was nearly half that of the contralateral control at postsurgical Days 7-10 owing to the depletion of germ cells. Concomitantly, the amounts of major glycerophospholipids (GPL) and sphingomyelin (SM) per testis decreased. Both these lipids lost their characteristic long-chain and very long-chain PUFA, notably 22:5n-6 and 28:4n-6, respectively, which suggests that these species are linked to the membranes of germ cells. In contrast, the amounts and concentrations of triglycerides (TG; triacylglycerols and 1-O-alkyl-2,3-diacylglycerols) and cholesterol esters (CE) increased several fold in the surviving cells (mainly Sertoli cells) in the cryptorchid testis. All these neutral lipids, but especially CE, accumulated large amounts of the major PUFA of the testis, 22:5n-6, as well as pentaenes with longer carbon chains (i.e., 24:5n-6 in TG and 28:5n-6 in CE). This accretion suggests that neutral lipids may store preformed PUFA coming from dying germ cell GPL and also VLCPUFA no longer needed as a source of PUFA destined to assemble new germ cell GPL. The lipid adjustments observed in cryptorchidism suggest a possible role for Sertoli cell CE in the turnover and conservation of PUFA within seminiferous tubules.
机译：本研究的目的是检查在大鼠实验性隐睾症的影响睾丸磷脂和中性脂质含有长链(C (18) - C(22))和非常长链(VLC) (C (24) - C(32)多不饱和多不饱和脂肪酸(PUFA)。睾丸是侧的近一半控制在7 - 10由于手术后的天生殖细胞的损耗。大量的主要glycerophospholipids (GPL)鞘磷脂(SM)睾丸下降。这些脂质失去了长链特征而且非常长链PUFA,尤其是22:5n-6和28:4n-6分别,这表明这些物种都与细菌的细胞膜细胞。不同浓度的甘油三脂(TG);triacylglycerols and1-O-alkyl-2 3-diacylglycerols)和胆固醇酯(CE)增加了几倍幸存的细胞(主要是支持细胞)患隐睾病的动物睾丸。特别是CE,积累了大量的主要PUFA的睾丸,22:5n-6,以及五烯与长碳链(例如,24:5n-6 TG和28:5n-6 CE)。表明中性脂质可能存储的PUFA来自生殖细胞GPL并死亡VLCPUFA不再需要作为PUFA的来源注定要组装新的生殖细胞GPL。观察隐睾症建议调整塞尔托利氏细胞CE的营业额可能的作用在精和PUFA守恒小管。

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