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首页> 外文期刊>Journal of the peripheral nervous system: JPNS >Guillain-Barre syndrome in Bangladesh: validation of Brighton criteria
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Guillain-Barre syndrome in Bangladesh: validation of Brighton criteria

机译：格林-巴利综合征在孟加拉国:验证布莱顿的标准

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摘要

Guillain-Barre syndrome has a diverse clinical phenotype related to geographical origin. To date, the majority of large-scale studies on Guillain-Barre syndrome (GBS) have been conducted in developed countries. We aimed to evaluate the key diagnostic features and assess the suitability of the Brighton criteria in 344 adult GBS patients from Bangladesh. All patients fulfilled the National Institute of Neurological Diseases and Stroke (NINDS) diagnostic criteria. Standardized data on demographic characteristics and clinical features, cerebrospinal fluid (CSF) analysis, and nerve conduction study (NCS) results were elaborated to measure the sensitivity of Brighton criteria. Most patients (88%) were admitted to hospital after the nadir weakness. Symmetrical weakness and reduced reflexes were found in 98% of patients. CSF albuminocytologic dissociation was detected in 238/269 (89%) cases and abnormal nerve physiology in 258/259 (>99%) cases. Only 27 (8%) patients received either intravenous immunoglobulin (IVIg) or plasmapheresis. In total, 200 (58%) patients met level 1 of the Brighton criteria; 97 (28%) patients met level 2; 42 (12%) patients met level 3; and 5 (2%) patients met level 4. This analysis showed that despite the heterogeneity of GBS in Bangladesh, the Brighton criteria showed a high sensitivity in the diagnosis of GBS.
机译：格林-巴利综合征有多样化的临床表型相关的地理起源。日期,大多数的大规模的研究格林-巴利综合征(GBS)进行在发达国家。关键诊断特性和评估布莱顿的适用性标准344年成人GBS患者从孟加拉国。完成国家研究所的神经疾病和中风(研究所)的诊断标准。标准化的数据在人口学特征和临床特征,脑脊液(CSF)分析和神经传导研究(nc)阐述了测量结果布莱顿的敏感性的标准。(88%)住院后的最低点的弱点。反射是98%的患者中发现的。albuminocytologic分离检测238/269(89%)例和神经生理异常在258/259(> 99%)的病例。接受静脉注射免疫球蛋白(丙种球蛋白)或血浆置换。符合一级布莱顿的标准;病人遇到2级;3;显示,尽管GBS的异质性孟加拉国、布莱顿的标准度高在GBS的诊断敏感性。

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