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首页> 外文期刊>Journal of basic and clinical physiology and pharmacology >Leaching from the stratum corneum does not explain the previously reported elevated potassium ion concentration in sweat
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Leaching from the stratum corneum does not explain the previously reported elevated potassium ion concentration in sweat

机译：浸出的角质层不解释先前报道高钾离子浓度在流汗

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Background: The purpose of this study was to determine if K+ is leached from the stratum corneum when sweat is present on the skin's surface. The results will help address whether sweat [K+] previously reported in the literature are artifactually elevated as a result of K+ leaching. Methods: Twelve (six female, six male) healthy volunteers participated in this study. After thorough skin cleansing and preparation with isopropyl alcohol and high-performance liquid chromatography-grade distilled water, three sites were chosen and a 50 uL drop of artificial sweat was pipetted directly onto the skin. The artificial sweat had a [K+] of 4 mEq-L1, an osmolality of 120 mosm-L1, and a pH of 6.0. Immediately following, a clear plastic cover slip (~6 cm2) with a shallow 0.8 cm2 convex impression in the center was applied over each drop, preventing evaporation. Each sample was allowed to sit on the forearm, under the plastic cover slip, for 10 min. Results: The mean (+SD) [K+] in 'artificial' sweat not exposed to the skin was measured to be 4.2+0.4 mEq-L1. After 10 min of exposure to the stratum corneum of the forearm, the artificial sweat had a mean (+SD) [K+] of 3.9+0.3 mEq-L1. There was no significant difference (p>0.05) in the [K+] between the control artificial sweat and the samples collected after 10 min of exposure to forearm skin. Conclusions: These results do not support the hypothesis that significant K+ leaching from the stratum corneum into standing sweat is the cause for the previously reported elevated sweat [K+],
机译：背景:本研究的目的确定K +的淋溶层皮肤的角质层,当汗水礼物表面。汗(K +)之前报道的文献由于K + artifactually升高吗浸出。健康的志愿者参与了这项研究。皮肤后彻底清洗和准备异丙醇与高性能液体chromatography-grade蒸馏水,三个网站选择和一个50 uL一滴用移液器吸取直接到人工汗液的皮肤。mEq-L1、同渗重摩120 mosm-L1和pH值6.0. 滑(~ 6 cm2)浅0.8 cm2凸印象在应用中心下降,防止蒸发。允许坐在前臂,塑料盖玻片上,10分钟。结果:均值(+ SD)(K +)在“人工”汗液不接触皮肤被测量是4.2 + 0.4 mEq-L1。分钟的曝光的角质层前臂,人工汗的意思是(+ SD)K + 3.9 + 0.3 mEq-L1。差异(p > 0.05) (K +)之间控制人工汗液和样品10分钟后收集的前臂的皮肤。重大K +浸出的假设角质层进入站是汗原因之前报道高架汗水(K +),

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