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首页> 外文期刊>Journal of basic and clinical physiology and pharmacology >Melatonin and vitamin C exacerbate Cannabis sativa-induced testicular damage when administered separately but ameliorate it when combined in rats
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Melatonin and vitamin C exacerbate Cannabis sativa-induced testicular damage when administered separately but ameliorate it when combined in rats

机译：褪黑激素和维生素C加剧大麻sativa-induced睾丸损伤但单独管理改善的时候结合的老鼠

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摘要

Background: The mechanisms involved in the sperma-totoxic effect of Cannabis sativa are inconclusive. The involvement of oxidative stress in male factor infertility has been well documented, and the antioxidative potential of melatonin and vitamin C in many oxidative stress conditions has been well reported. This study sought to investigate whether melatonin and vitamin C will ameliorate C. sativa-induced spermatotoxicity or not. Methods: Fifty-five (55) male albino rats (250-300 g) were randomly divided in a blinded fashion into five oral treatment groups as follows: group I (control, n=5) received 1 mL/kg of 10% ethanol for 30 days; groups Ha, lib, and lie (n=5 each) received 2 mg/kg C. sativa for 20, 30, and 40 days, respectively; groups Ilia, Illb, and IIIc (n=5 each) received a combination of 2 mg/kg C. sativa and 4 mg/kg melatonin for 20, 30, and 40 days, respectively; groups IVa, IVb, and IVc (n=5 each) received a combination of 2 mg/kg C. sativa and 1.25 g/kg vitamin C for 20, 30, and 40 days, respectively; group V (n=5) received a combination of 2 mg/kg C. sativa, 4 mg/kg melatonin, and 1.25 g/kg vitamin C for 30 days.
机译：背景:参与的机制sperma-totoxic大麻的影响不确定。在男性因素不育记录和的抗氧化潜力褪黑素在许多氧化应激和维生素C条件已经被报道。试图探讨褪黑激素是否和维生素C将改善C . sativa-inducedspermatotoxicity与否。男性患白化病老鼠(250 - 300克)是随机的盲法的方式分为五个口服治疗组:组我控制,n = 5)收到1毫升/公斤以上的10%的乙醇为30天;组Ha、自由和谎言(n = 5)收到2毫克/公斤c .漂白亚麻纤维卷20 30和40天,分别;每个)收到的组合2毫克/公斤的可能褪黑激素和4毫克/公斤20、30、40天,分别;收到2毫克/公斤的结合,1.25克/公斤维生素C 20、30和40天,分别;结合2毫克/公斤c、马唐4毫克/公斤褪黑素,维生素C和1.25克/公斤30天。

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