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首页> 外文期刊>Journal of basic and clinical physiology and pharmacology >A collaboration investigating endocannabinoid signalling in brain and bone
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A collaboration investigating endocannabinoid signalling in brain and bone

机译：协作调查神经的信号在大脑和骨骼

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Investigations into the cellular and molecular mechanisms underlying the psychoactive effects of cannabis preparations have led to the discovery of the endocannabinoid system. Interest in the central nervous system effects was initially the main focus of the research, but it soon became evident that the endocannabinoid system affects virtually every organ. The research field has therefore experienced a tremendous growth over the last decade and is now truly interdisciplinary. This short review provides a personal account of an interdisciplinary collaboration between Itai Bab from the Hebrew University of Jerusalem and the author. It describes the discovery of the endocannabinoid system in bone and the analysis of its functions. I am summarising the role of CB1 signalling as a modulator of sympathetic inhibition of bone formation. Thus, activation of CB1 receptors on sympathetic nerve terminals in bone, presumably from endocannabi-noids released from apposing osteoblasts, reduces the inhibition of bone formation of sympathetic norepineph-rine. CB2 receptors on osteoblasts and osteoclasts also modulate the proliferation and functions of these cells. Thus, activation of CB2 stimulates bone formation and represses bone resorption, whereas the genetic disruption of CB2 results in an osteoporosis-like phenotype. This signalling mechanism is clinically relevant, as shown by the association of polymorphisms in the CB2 receptor gene, CNR2, with bone density and osteoporosis. Finally, the review provides a summary of the recently discovered role of endocannabinoid signalling in one elongation. This review will also discuss the benefits of interdisciplinary and international collaborations.
机译：细胞和分子进行调查机制的精神影响大麻制剂导致发现的神经系统。最初的中枢神经系统的影响研究的重点,但它很快明显,神经系统的影响几乎所有的器官。因此经历了一个巨大的增长过去十年,现在是真的跨学科。一个跨学科的个人账户合作Itai巴布从希伯来语耶路撒冷和作者大学。描述了神经的发现系统的骨头和分析功能。我总结CB1信号作为一个的角色调制器的交感神经抑制骨形成。交感神经终端在骨,大概从endocannabi-noids释放添成骨细胞,减少骨的抑制交感norepineph-rine的形成。成骨细胞和破骨细胞受体调节的增殖和功能细胞。形成和抑制骨吸收,而CB2的基因中断导致的osteoporosis-like表现型。机制是临床相关,如图所示协会CB2受体的多态性基因,CNR2,骨密度和骨质疏松症。最后,回顾总结了最近发现神经的作用信号在一个伸长。也讨论跨学科的好处与国际合作。

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