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首页> 外文期刊>Journal of basic and clinical physiology and pharmacology >Are the endocannabinoid-like compounds /V-acyl aminoacids neuroprotective after traumatic brain injury?
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Are the endocannabinoid-like compounds /V-acyl aminoacids neuroprotective after traumatic brain injury?

机译：endocannabinoid-like化合物/ V-acyl吗创伤性脑后氨基酸神经受伤吗?

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摘要

In recent years, a library of approx. 70 JV-acyl aminoacids (NAAAs) was discovered in the rat brain. A particular member of this family of compounds is ara-chidonoyl serine (AraS), which has generated special interest as a potential therapy for traumatic brain injury (TBI). This is due to its structural similarity to the endo-cannabinoid (eCB) 2-arachidonoyl glycerol (2-AG), which was previously shown to be beneficial in the recovery in a closed head injury model of TBI. Indeed, AraS exerted eCB-mediated neuroprotection, which was evident in numerous aspects related to the secondary damage characterizing TBI. These findings promoted broadening of the research to additional compounds of the NAAA family that share a structural similarity to AraS, namely, palmi-toyl serine (PalmS) and oleoyl serine. The latter did not exhibit any improvement in recovery, whereas the former displayed some neuroprotection, albeit inferior to 2-AG and AraS, via unknown mechanisms. Interestingly, when a combined treatment of 2-AG, AraS and PalmS was tested, the overall effect on the severity score was inferior to their individual effects, suggesting not only a lack of direct or indirect synergism, but also possibly some spatial hindrance
机译：近年来,大约的图书馆。氨基酸(NAAAs)被发现在老鼠大脑。化合物是ara-chidonoyl丝氨酸(阿拉斯)生成的特殊利益作为一个潜在的吗治疗创伤性脑损伤(TBI)。由于其结构相似endo-cannabinoid (eCB) 2-arachidonoyl甘油(2-AG)以前所示有利于经济复苏在一个封闭的头损伤的创伤性脑损伤模型。eCB-mediated神经保护,这是显而易见的在许多方面相关的次要的损伤创伤性脑损伤的特征。促进扩大额外的研究NAAA家庭共享的化合物结构相似性阿拉斯,即palmi-toyl丝氨酸(手掌)和油酰丝氨酸。没有表现出任何改善复苏,而前者显示一些神经保护,尽管不如2-AG阿拉斯,通过未知机制。治疗2-AG,阿拉斯和手掌测试总体影响严重程度得分差个人影响,表明不仅缺乏直接或间接合作,但也可能一些空间阻碍

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