...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of basic and clinical physiology and pharmacology >Antithrombotic and cytotoxic activities of four Bangladeshi plants and PASS prediction of their isolated compounds
【24h】

Antithrombotic and cytotoxic activities of four Bangladeshi plants and PASS prediction of their isolated compounds

机译：血栓形成和细胞毒性四个活动孟加拉国植物和通过预测的孤立的化合物

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: This study aims to investigate whether tested organic extracts possess antithrombotic properties with minimal or no toxicity and to predict the activity of some of their isolated compounds. Methods: An in vitro thrombolytic model was used to check the clot lysis effect of four Bangladeshi herbal extracts viz., roots of Curculigo recurvata W.T. Aiton (Sati-pata), leaf of Amorphophallus bulbifer Roxb. (Olkachu), leaf of Phyllanthus sikkimensis Muell. Arg., and whole plant of Thunbergia grandiflora Roxb. (Nillata) using streptokinase as a positive control and water as a negative control. Cytotoxicity was screened by brine shrimp lethality bioassay using vincristine sulfate as positive control. In silico prediction of activity spectra for substances (PASS) prediction was applied for phytoconstituents, namely, nyasicoside, glucomannan, grandifloric acid, serine, and alanine. Results: Using an in vitro thrombolytic model, C. recurvata, A. bulbifer, P. sikkimensis, and T. grandiflora showed 28.10±1.64%, 42.47+1.96% 32.86+1.92%, and 25.51±1.67% of clot lysis, respectively. Reference drug streptokinase exhibited 75.00±3.04% clot lysis. Examined herbs showed significant (p< 0.001) percentage (%) of clot lysis compared to negative control. In brine shrimp cytotoxic assay, C. recurvata, A. bulbifer, P. sikkimensis, and T. grandiflora showed LC_(50) values 210.64±3.44, 98.51±1.47, 187.29±2.01, and 386.43+3.02 mug/mL, respectively, with reference to vincristine sulfate (LC_(50) 0.76+0.04). PASS predicted that examined phytoconstituents have a wide range of biological activity. Conclusions: Through our study it was found that A. bulbifer and P. sikkimensis could be considered as very promising and beneficial thrombolytic agents.
机译：背景:本研究的目的是调查是否测试了有机提取物具有抗血栓形成的极少或没有毒性和属性预测他们的一些孤立的活动化合物。模型是用来检查血栓溶解的影响四个孟加拉草药提取即。,的根源的菲sikkimensis Muell。使用链激酶作为积极的控制水是一种消极的控制。通过盐水虾杀伤力生物测定使用的筛选硫酸长春新碱作为积极的控制。计算机预测活动的光谱物质(通过)预测申请植物成份,即nyasicoside,葡甘露聚糖,grandifloric酸、丝氨酸和丙氨酸。模型中,c . recurvata a . bulbifer p . sikkimensis和t大花蔷薇显示28.10±1.64%,42.47 + 32.86 + 1.92%, 1.96%和25.51±1.67%的凝块分别溶解。表现出75.00±3.04%血栓溶解。显示显著(p < 0.001)的百分比(%)血栓溶解而负控制。虾细胞毒性试验,c . recurvata A。bulbifer, p·sikkimensis and t grandiflora显示LC_(50)值210.64±3.44,98.51±1.47,187.29±2.01和386.43 + 3.02杯/毫升,长春新碱分别与参考硫酸(LC_(50) 0.76 + 0.04)。检查植物成份有广泛的生物活性。研究发现bulbifer和P。sikkimensis可以被认为是很有前途的和有益的溶栓药物。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号