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首页> 外文期刊>Journal of basic and clinical physiology and pharmacology >Phenotypic homogeneity with minor deviance in osmotic fragility of Sahel goat erythrocytes in non-ionic sucrose media during various physiologic states
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Phenotypic homogeneity with minor deviance in osmotic fragility of Sahel goat erythrocytes in non-ionic sucrose media during various physiologic states

机译：与小异常表型同质性红细胞渗透脆性的荒漠草原羊红细胞非离子的蔗糖在各种媒体生理状态

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Background: Erythrocyte swelling in non-ionic sucrose media and the subsequent osmotic lysis are influenced by mechanisms of regulatory volume adjustment and osmotic water permeability. Kinetics of transmembrane water and ion fluxes in varied physiologic states may determine the phenotype of erythrocyte osmotic fragility (EOF) and affect estimates of EOF. Methods: Effects of sex, age, late pregnancy (third trimester) and lactation on the haemolysis of Sahel goat erythrocytes incubated in a series of hyposmotic non-ionic sucrose media were investigated. Results: The fragiligram was sigmoidal in 72 (97%) out of 74 goats. Two male (3%) goats with low and high extreme median erythrocyte fragilities (MEF), had non-sigmoidal curves. The mean fragilities at osmolarities of 30-300 mosmol/L of sucrose and the mean osmolarities responsible for 10%-90% haemolysis (CH_(10)-CH_(90)) were not significantly different between males and non-pregnant dry (NPD) females, amongst the age groups and between pregnant or lactating and NPD female goats. The MEF (CH_(50)) of the goats were at osmolarities of 126-252 mosmol/L (median of data: 171 mosmol/L) with a mean of 175.24±16.20 mosmol/L. Therefore, phenotypic homogeneity of EOF occurred with minor deviance, since EOF variables were not differentiated by sex, age, late pregnancy or lactation. Conclusions: Physiologic states of the goat did not affect EOF phenotype in non-ionic sucrose media. Sigmoidal fragility phenotype seemed to be homogeneously conserved by osmoregulatory mechanisms not partitioned by sex, age, late pregnancy or lactation, but a minor non-sigmoi-dal curve might have occurred due to altered erythrocyte osmotic behaviour that would require further investigation.
机译：背景:红细胞在非离子肿胀蔗糖媒体和随后的渗透溶解影响机制的监管卷调整和渗透水渗透率。水和离子跨膜通量动力学不同的生理状态可能决定红细胞渗透脆性的表现型(EOF)并影响EOF的估计。性别、年龄、怀孕后期(第三阶段)哺乳期的红血球溶解萨赫勒山羊红细胞在一系列hyposmotic孵化非离子的蔗糖媒体进行调查。结果:fragiligram于72年s形(97%)的74个山羊。低和高极端平均红细胞脆弱性(MEF), non-sigmoidal曲线。脆弱性意味着30 - 300的渗透性mosmol蔗糖/ L和渗透性负责10% - -90%溶血(CH_ (10) -CH_(90))并不显著不同男性和没有怀孕干燥(NPD)女性,在年龄组之间怀孕或哺乳期,NPD雌性山羊。MEF (CH_(50))的山羊在渗透性126 - 252年mosmol / L(数据的中位数:171mosmol / L)平均值为175.24±16.20 mosmol / L。因此,发生表型EOF的同质性与小异常,因为没有EOF变量按性别、年龄、怀孕后期泌乳。山羊不影响非离子的EOF表型蔗糖的媒体。似乎均匀守恒渗透调节的机制不分区性,年龄、怀孕或哺乳后期,但未成年人non-sigmoi-dal曲线可能发生由于这将改变红细胞渗透行为需要进一步调查。

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