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首页> 外文期刊>Journal of basic and clinical physiology and pharmacology >Analgesic properties of aqueous leaf extract of Haematostaphis barteri: involvement of ATP-sensitive potassium channels, adrenergic, opioidergic, muscarinic, adenosinergic and serotoninergic pathways
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Analgesic properties of aqueous leaf extract of Haematostaphis barteri: involvement of ATP-sensitive potassium channels, adrenergic, opioidergic, muscarinic, adenosinergic and serotoninergic pathways

机译：水叶提取物的镇痛属性Haematostaphis barteri:参与ATP-sensitive钾离子通道、肾上腺素能opioidergic, muscarinic adenosinergic and含血清素的途径

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Background: Pain is the most common cause of patients seeking medical advice as a result of its association with different pathologies. This study evaluated the antinoci-ceptive property of Haematostaphis barteri as well as the possible mechanism(s) associated with its antinociceptive property. Methods: Mice were administered Я. barteri (30-300 mg kg~(-1); p.o.), followed by intraplantar injection of 10 muL of 5% formalin into the hind paws. The pain score was determined for 1 h in the formalin test. The possible nociceptive pathways involved in the antinociceptive action of H. barteri were determined by pre-treating mice with theophylline (5 mg kg~(-1), a non-selective adenosine receptor antagonist), naloxone (2 mg kg~(-1), a non-selective opioid receptor antagonist), glibenclamide (8 mg kg~(-1); an ATP-sensitive K~+ channel inhibitor), and atropine (3 mg kg~(-1); non-selective muscarinic antagonist). Results: H. barteri (30-300 mg kg~(-1)) significantly and dose dependently precluded both first and second phases of nociception. Pre-treatment with naloxone had no effect on the analgesic activities of H. barteri in the first phase. Again, pre-treatment with atropine and glibenclamide did not significantly reverse the neurogenic antinociception of the extract in phase 1. However, theophylline reversed the analgesic effect of the extract in the first phase. In phase 2, theophylline had no effect on the analgesic activities of the extract. Naloxone, atropine, and glibenclamide significantly blocked the antinociception of H. barteri in the inflammatory phase of the formalin test. Conclusions: H. barteri possesses antinociceptive property mediated via the opioidergic, adrenergic, muscarinic, ATP-sensitive K~+ channels, and adenosinergic nociceptive pathways.
机译：背景:疼痛是最常见的原因由于患者寻求医疗建议它与不同的病态。研究评估的antinoci-ceptive属性Haematostaphis barteri以及可能的机制(s)与其antinociceptive关联财产。barteri(30 - 300毫克公斤~ (1);intraplantar注入10 muL 5%福尔马林进入后爪子。福尔马林测试1 h。疼痛的途径参与的h . barteri antinociceptive行动由预处理小鼠茶碱(5毫克公斤~(1)的腺苷受体拮抗剂)、纳洛酮(2毫克公斤~(1),一个无选择性阿片受体拮抗剂)格列本脲(8毫克公斤~ (1);通道抑制剂)和阿托品(3毫克公斤~ (1);无选择性的毒蕈碱的拮抗剂)。barteri(30 - 300毫克公斤~(1))明显剂量依赖性杜绝第一和第二伤害感受的阶段。纳洛酮没有对镇痛的影响h . barteri活动在第一阶段。同样,与阿托品预处理格列本脲没有显著逆转神经源性镇痛效应的提取阶段1。提取物的镇痛效果阶段。提取物的镇痛药活动。纳洛酮、阿托品和格列本脲明显阻止H的镇痛效应。barteri福尔马林的炎症阶段测试。antinociceptive财产通过介导的opioidergic,肾上腺素能、毒蕈碱的ATP-sensitive K ~ +渠道,adenosinergic疼痛的途径。

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