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首页> 外文期刊>Proceeding of the Singapore National Academy of Science >Signal Transduction in Hepatocellular Carcinoma: Insights from Zebrafish
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Signal Transduction in Hepatocellular Carcinoma: Insights from Zebrafish

机译：信号转导在肝细胞癌:从斑马鱼

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摘要

The zebrafish has been an increasingly popular animal model for human diseases as it offers the combined advantages compared to various animal models and cell based assays; in particular, the feasibility of high throughput studies as an economical vertebrate model. In this past decade, we and several other laboratories have developed various hepatocellular carcinoma (HCC) models using the zebrafish and demonstrated the conservation of HCC between zebrafish and human at both histopathological and molecular levels. In this review, we focus on the conservation of signal transductions during hepatocarcinogenesis between zebrafish and human. Based on existing zebrafish HCC models, indeed many alterations of signal pathways that cause human liver cancers can also result in HCC in zebrafish, such as Ras pathway, EGFR pathway, Wng/β-catenin pathway, TGF-β pathway, PI3K/AKT pathway, JAK/STAT pathway, Hippo pathway, src tyrosine kinase pathway, etc. In future, zebrafish may be used for better quantification of signaling molecules and thus to aid development of more effective therapeutic methods.
机译：斑马鱼已成为越来越受欢迎的人类疾病的动物模型,因为它提供了结合优势相比,各种各样的动物模型和基于细胞的检测;作为一种高通量研究的可行性经济的脊椎动物模型。我们和其他几个实验室开发了各种各样的肝细胞癌(HCC)模型使用斑马鱼和演示了保护肝细胞癌在斑马鱼和人类之间组织病理学和分子水平。在本文中,我们专注于保护信号转导在hepatocarcinogenesis斑马鱼和人类之间的关系。斑马鱼肝细胞癌模型,事实上许多改变信号通路导致人类肝脏的癌症也可以导致斑马鱼肝细胞癌,如拉通路,EGFR通路,绕线/β连环蛋白通路,TGF -βpathway, PI3K / AKT pathway, JAK /统计src酪氨酸激酶通路,河马通路途径等。为更好的量化信号分子从而帮助更有效的发展治疗方法。

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