• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceeding of the Singapore National Academy of Science >Scaffold Proteins and their Roles in Human Diseases
【24h】

Scaffold Proteins and their Roles in Human Diseases

机译：脚手架蛋白在人类和他们的角色疾病

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Scaffold proteins are critical regulators of important cell signaling pathways. Though scaffolds are not stringently defined in meaning, they are known to interact with numerous components of a signaling pathway, binding and bridging them into distinct and functional complexes. They control signal transduction and assist the localization of pathway components (organized in complexes) to definite regions of the cell such as the endosomes, plasma membrane, the cytoplasm, mitochondria, Golgi,and the nucleus. Years of research in this field have revealed the versatility of this class of protein and the important role it plays in maintaining the normal functions of the human body. Here, we discuss the role of several scaffold proteins which are implicated in important signaling pathways that play important roles in cardiac diseases, metabolic diseases, neurological disorders, and cancer. Their versatility and functions in human diseases make them attractive drug targets, several of which have been investigated in clinical trials. Future studies of scaffold proteins should give us an in-depth knowledge of how cell signaling works in normal and pathological conditions and would offer avenues to disrupt harmful cellular pathways to circumvent diseases.
机译：支架蛋白的管理者至关重要重要的细胞信号通路。支架没有严格定义的意义,他们是已知的与众多组件的信号通路,绑定和桥接成不同的和功能复合物。协助定位的路径组件(组织的复合物)明确的地区细胞如核内体、质膜,细胞质中线粒体,高尔基体,原子核。揭示了这类蛋白质的多功能性和维持具有重要的作用人体的正常功能。讨论几个脚手架蛋白的作用涉及重要的信号吗通路在心脏扮演重要的角色疾病、代谢性疾病、神经系统疾病和癌症。功能在人类疾病使他们有吸引力药物靶点,其中一些进行临床试验。脚手架蛋白应该给我们深入了解细胞信号在正常工作和病理条件和将提供途径来破坏有害细胞的途径规避疾病。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号