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首页> 外文期刊>Proceeding of the Singapore National Academy of Science >LncRNAs: Master Regulators in Disease and Cancer
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LncRNAs: Master Regulators in Disease and Cancer

机译：LncRNAs:主监管机构在疾病和癌症

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Long non-coding RNA (lncRNA) is a new class of endogenous molecules identified in recent years. Studies on the cancer transcriptome have identified a number of IncRNAs with distinct expression patterns in different types of cancer, indicating that this populous group of molecules can modulate cancer progression. In addition, advances in revealing the molecular principles of cancer- associated IncRNAs made them amenable for therapeutic intervention. Although more than 50,000 IncRNAs have been identified, their functions in cellular homeostasis and pathophysiological processes remain largely uncharacterized. In this review, we summarize cancer-related IncRNAs that have been identified in recent years and discuss their mechanistic roles as oncogenes or tumor suppressors. These findings provide insights into clinical application of IncRNAs as biomarkers or therapeutic targets.
机译：长非编码RNA (lncRNA)是一个新类内源性分子近年来确定。转录组研究癌症确定一些IncRNAs截然不同表达模式在不同类型的癌症,表明这群人口众多的分子可以调节癌症恶化。揭示了进步分子的原则癌症相关IncRNAs使他们顺从治疗性干预。50000年IncRNAs已确定,他们的在细胞体内平衡和功能病理生理过程在很大程度上仍无特征。癌症相关IncRNAs已确定近年来,讨论他们的机械作为癌基因和肿瘤抑制的作用。研究结果为临床提供见解应用IncRNAs作为生物标志物或治疗的目标。

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