Control of Iron Availability in Cancer by MicroRNAs

Kamesh R. Babu; Lei Sun

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Control of Iron Availability in Cancer by MicroRNAs

机译：控制癌症的铁可用性

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摘要

Iron is an essential nutrient required for normal cellular functions, growth, and proliferation. Iron homeostasis is maintained at the cellular and systemic levels by strict regulation of genes involved in the process of iron uptake, storage, export, and surveillance of iron levels. Cellular iron homeostasis is dysregulated in cancer to sustain rapid growth and proliferation. Cellular iron levels are increased in cancer by manipulating the expression of genes involved in iron metabolism. Recent studies show that a class of small non-coding RNA known as microRNA (miRNA) play a major role in the control of iron metabolism. This review summarizes the significance of iron in cancer prognosis and how miRNAs regulate the expression of genes involved in iron metabolism to increase the cellular iron availability in cancer.

机译：铁是一个重要的营养所需的正常细胞功能、生长和增殖。铁在细胞保持体内平衡和系统性水平基因的严格监管参与铁吸收的过程中,存储,出口,铁和监测水平。铁体内平衡是在癌症特异表达维持快速增长和扩散。铁含量增加癌症操纵基因的表达铁代谢。小非编码RNA被称为微RNA (microRNA的)在铁的控制发挥重要作用新陈代谢。铁在癌症预后的意义和方式microrna调节基因的表达铁代谢增加细胞铁可用性癌症。

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《Proceeding of the Singapore National Academy of Science》 |2020年第2期|61-77|共17页
作者
Kamesh R. Babu; Lei Sun;
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作者单位

Cardiovascular and Metabolic Disorders Program Duke-NUS Medical School, 8 College Road Singapore 169857, Singapore;

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原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Iron; iron homeostasis; GenesMicroRNAsSmall Untranslated RNAiron metabolismCellscontent of iron;

机译：翻译RNAiron metabolismCellscontent的铁;

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1. Zeptomole Imaging of Cytosolic MicroRNA Cancer Biomarkers with A Light-Controlled Nanoantenna [J] . Yang Song, Xiaoli Cai, Grayson Ostermeyer, 纳微快报：英文版 . 2021,第12期
2. MicroRNA-related genetic variants in iron regulatory genes, dietary iron intake, microRNAs and lung cancer risk [J] . Zhang L., Ye Y., Tu H.Hildebrandt M. A.Zhao L.Heymach J. V.Roth J. A.Wu X. Annals of oncology: official journal of the European Society for Medical Oncology . 2017,第5期

机译：MicroRNA-related genetic variants in iron regulatory genes, dietary iron intake, microRNAs and lung cancer risk
3. MicroRNA-129-5p is regulated by choline availability and controls EGF receptor synthesis and neurogenesis in the cerebral cortex [J] . Trujillo-Gonzalez Isis, Wang Yanyan, Friday Walter B.Vickers Kasey C.Toth Cynthia L.Molina-Torres LorianSurzenko NataliaZeisel Steven H. The FASEB Journal . 2019,第3期

机译：MicroRNA-129-5p is regulated by choline availability and controls EGF receptor synthesis and neurogenesis in the cerebral cortex
4. Comparison of the availability of iron in white bread, fortified with iron powder, with that of iron naturally present in wholemeal bread [J] . H. V. Hart journal of the science of food and agriculture . 1971,第7期

机译：Comparison of the availability of iron in white bread, fortified with iron powder, with that of iron naturally present in wholemeal bread
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机译：用经验贝叶斯弹性网分析Colon Cancer中的MicroRNA简介
6. PART I. THE DETECTION OF ELECTRON POLARIZATION BY MOLLER SCATTERING. PARTII. ENERGY LEVELS IN THE NEAR-HARMONIC NUCLEI IRON-56, IRON-58 AND NICKEL-60. [D] . LEVINE, NATHAN. 1958

机译：第一部分：利用莫勒散射法检测电子极化。第二部分近钟形核IRON-56，IRON-58和NICKEL-60的能量水平。
7. A comparison of performance of Deca Iron and Triple Deca Iron ultra-triathletes [O] . Beat Knechtle, Thomas Rosemann, Romuald Lepers, -1

机译：Deca Iron和Triple Deca Iron超铁人三项运动员的性能比较
8. Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells [O] . Li Ruibin, Wu Renan, Zhao Liang, 2011

机译：Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells
9. Tratamiento para el Cancer de Prostata: Guia para Hombres con Cancer Localizado de Prostata (Treating Prostate Cancer: A Guide for Men with Localized Prostate Cancer). [R] . 2008

机译：Tratamiento para el Cancer de prostata：Guia para Hombres con Cancer Localizado de prostata（治疗前列腺癌：患有局部前列腺癌的男性指南）。

Control of Iron Availability in Cancer by MicroRNAs

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