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首页> 外文期刊>Proceeding of the Singapore National Academy of Science >MiRNA:RBP Interplay as a Key Regulatory Element in Health and Disease
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MiRNA:RBP Interplay as a Key Regulatory Element in Health and Disease

机译：microrna: RBP相互作用作为一个关键监管元素健康和疾病

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Numerous crosstalk interactions between RNA-binding proteins (RBPs) and microRNAs (miR- NAs) have been recently reported, unveiling the complexity and importance of gene expression modulation in health and disease. They control physiological processes such as stem cell maintenance, neuronal development or energetic metabolism, but are also responsible for pathological conditions, such as muscle waste and dystrophies, atherosclerosis, obesity and cancer. MiRNAs and RBPs are two of the well-studied post-transcriptional regulators and they may even reciprocally regulate themselves. MiRNAs can act on RBPs expression while RBPs modulate miRNA biogenesis, function and degradation. RBPs and miRNAs modulate mRNA expression at different levels, affecting their stability, splicing and translation efficiency through either competition for overlapping binding or modulation of mRNA structure by binding, but several other forms of interaction have been described. In this review, we will address the current bibliography regarding miRNA:RBP interactions and crosstalk events as well as their implications in health and disease.
机译：无数串扰之间的相互作用RNA-binding proteins RBPs)和microRNAs (miR -NAs)最近报道,揭幕基因表达的复杂性和重要性调制在健康和疾病。干细胞等生理过程维护、神经发展或精力充沛新陈代谢,但也负责病理条件下,如肌肉和浪费营养不良、动脉硬化、肥胖和癌症。microrna和RBPs是两个研究转录后的监管者,他们甚至可能相反地调节自己。RBPs表达而RBPs调节microrna生物起源、功能和退化。microrna调节mRNA表达不同水平,影响其稳定性、拼接和通过翻译效率的竞争重叠的绑定或调制的信使rna结构由绑定,但其他一些形式的描述了交互。我们将解决当前书目关于microrna: RBP交互和相声事件及其影响健康和疾病。

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