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首页> 外文期刊>Proceeding of the Singapore National Academy of Science >Simplicity from Complexity - MicroRNAs and the Maintenance of Skin Homeostasis
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Simplicity from Complexity - MicroRNAs and the Maintenance of Skin Homeostasis

机译：从复杂性——小分子核糖核酸和简单维护皮肤内稳态

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Skin homeostasis is indispensable for terrestrial life. The skin, sitting at the interface between the dry external environment and the aqueous interior, acts as a barrier to delimit each from the other. Maintaining this barrier function is critical - if it is compromised, pathogen ingress and water loss may have potentially severe consequences. Skin function is supported by an intricate regulatory network incorporating both protein-coding genes as well as non-coding RNA transcripts. This review will focus on microRNAs, a subset of non-coding RNAs which target specific messenger RNAs for post-transcriptional repression. MicroRNAs regulate every aspect of skin biology, from initial cell fate determination during embryogenesis, to steady state keratinocyte maturation and barrier renewal, as well as coordination of the healing process in response to skin damage. An increased appreciation for the role of microRNAs in skin pathologies not only sheds light on the importance of these small RNAs in healthy skin function, but also provides an expanding repertoire of potential therapeutic targets through which these conditions may be addressed. Mammalian skin appears simple. Its core function is to shield the body from the external environment. Water must be retained to sustain life, whilst harmful pathogens and other environmental insults must be kept out. This simplicity in function belies the array of intricate processes necessary to maintain the skin's barrier function - multiple series of highly-ordered molecular and cellular events control constant epidermal rejuvenation, as well as rapid repair of any epithelial damage sustained. For internal homeostasis to be maintained, epithelial integrity is essential, and contingent upon precise spatiotemporal control of protein expression in the skin.
机译：皮肤为陆地体内平衡是必不可少的的生活。干燥的外部环境和水内部,划定各作为一个障碍另一个。关键——如果是妥协,病原体进入和水可能潜在的严重损失的后果。复杂的监管网络整合蛋白质编码基因以及非编码RNA记录。针对特定的非编码rna的一个子集信使rna的转录后镇压。皮肤生物学,从最初的细胞命运在胚胎发生过程中,稳定的决心角化细胞的成熟和障碍更新,以及协调的愈合针对皮肤损伤过程。感谢小分子核糖核酸的作用在皮肤上病态不仅揭示了这些小分子rna在健康皮肤的重要性功能,还提供了一个扩展的潜在的治疗靶点通过这些条件可能会解决。哺乳动物的皮肤看起来简单。保护身体免受外部吗环境。生活,而有害的病原体和其他环境侮辱必须保持。简单的数组函数掩盖复杂的过程需要维护皮肤的屏障功能,多个系列此消彼长。分子和细胞活动控制常数表皮复兴快速修复任何上皮的损伤持续。维护上皮的完整性是至关重要的,取决于准确的时空控制蛋白表达在皮肤上。

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