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首页> 外文期刊>The journal of applied laboratory medicine. >Pathobiology, Diagnosis, and Current Biomarkers in Neuromyelitis Optica Spectrum Disorders
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Pathobiology, Diagnosis, and Current Biomarkers in Neuromyelitis Optica Spectrum Disorders

机译：病理学、诊断和当前的生物标志物视Neuromyelitis谱系障碍

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摘要

Background: Neuromyelitis optica spectrum disorder (NMOSD) is characterized by chronic inflammation of the central nervous system (CNS), particularly the optic nerves and spinal cord. Although it displays some clinical features similar to multiple sclerosis (MS), the etiology and treatment are distinct, and therefore accurate diagnosis is essential. Autoantibodies targeting the water channel protein aquaporin-4 (AQP4) and the myelin sheath protein myelin oligodendrocyte glycoprotein are the major antigen-specific serological biomarkers known to date, with destruction of astrocytes as the primary mode of CNS damage in AQP4-positive disease. Content: This mini-review summarizes the pathobiology, clinical features, and current methods of serological testing used to assess NMOSD and differentiate this disorder from MS. A brief summary of emerging therapies is also presented. Summary: NMOSD can be distinguished from MS through a combination of clinical findings, imaging investigations, and serological analysis. Seronegative cases are particularly difficult to diagnose and can pose a challenge to clinicians. As knowledge deepens, new therapies and biomarkers are expected to improve treatment of this rare debilitating disease.
机译：背景:视Neuromyelitis谱系障碍(NMOSD)的特点是慢性炎症中枢神经系统(CNS),特别是视觉神经和脊髓。显示一些临床特征相似多发性硬化(MS)、病因和治疗是不同的,因此准确诊断是至关重要的。水通道蛋白aquaporin-4 (AQP4)和髓鞘蛋白髓少突细胞糖蛋白是主要抗原血清生物标记日期,星形胶质细胞的破坏的主要模式中枢神经系统损伤AQP4-positive疾病。本文着重总结了病理学,临床特征和当前的方法用于评估NMOSD和血清学检测区分这种疾病从一个简短的女士总结新兴疗法。简介:NMOSD可以区分开来通过结合临床发现,成像调查和血清学分析。血清反应阴性的情况下尤其困难对临床医生诊断,可以构成挑战。随着知识的加深,新疗法生物标记有望改善治疗这种罕见的使人衰弱的疾病。

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