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Autoantibodies in Common Connective Tissue Diseases: A Primer for Laboratory Professionals

机译:自身抗体在常见的结缔组织疾病:实验室人员的底漆

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Background: Autoimmune connective tissue disorders are a significant health concern throughout the world with an estimated prevalence of 3% to 5%. They are associated with a variety of autoantibodies that play roles in their diagnosis, risk stratification, prognostication, and/or management. While some autoantibodies have been well-characterized for use in clinical laboratories, many more are in the research stage. Rapid transition from research to clinical practice, lack of clinical guidelines, and harmonization across a rapidly growing number of commercially available tests create numerous challenges to clinicians and laboratories. Content: This article briefly discusses common connective tissue disorders and their association with well-known autoantibodies, describes current methods used in clinical laboratories, and outlines their advantages and limitations in the context of these diseases. Summary: Understanding the role of specific autoantibodies and various methodologies for autoantibody testing are important for laboratory professionals who may be introducing/repatriating new tests, updating existing tests, or advising clinicians/patients about testing options/results. Collaboration between laboratory professional staff and clinicians, around the advantages and limitations of each methodology, is also important in their appropriate clinical utilization.
机译:背景:自身免疫性结缔组织疾病中一个重要的健康问题吗世界上估计患病率为3%到5%。他们用各种相关联自身抗体,在他们扮演的角色诊断、危险分层、预测,和/或管理。被用于临床特征明显实验室,更多的研究阶段。实践中,缺乏临床指南,以及在快速增长的数量的协调创建许多商用测试临床医生和实验室的挑战。内容:本文简要讨论了常见结缔组织疾病和他们的协会与著名的自身抗体,描述当前方法在临床实验室、和概述了他们的优势和局限性这些疾病。特定的自身抗体和不同的角色自身抗体检测方法对实验室的专业人士可能会很重要介绍/遣返新的测试,更新现有的测试,或建议临床医生/病人关于测试选项/结果。实验室专业人员和之间临床医生、优点和局限性每一个方法,他们也很重要适当的临床运用。

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