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首页> 外文期刊>The journal of applied laboratory medicine. >Reproductive Endocrinology Reference Intervals for Transgender Men on Stable Hormone Therapy
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Reproductive Endocrinology Reference Intervals for Transgender Men on Stable Hormone Therapy

机译：生殖内分泌学参考区间变性人稳定的激素疗法

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Background: Gender-affirming therapy with testosterone is commonly prescribed to aid in the masculinization of transgender men. Sex-hormone concentrations are routinely measured, but interpretation of results can be difficult due to the lack of published reference intervals. Methods: Healthy transgender individuals who had been prescribed testosterone (n = 82) for at least a year were recruited from internal medicine and primary care clinics that specialize in transgender medical care. Total testosterone and estradiol were measured using immunoassay and mass spectrometry; LH, FSH, SHBG, prolactin, progesterone, anti-Mullerian hormone (AMH), and dehydroepiandrosterone sulfate (DHEAS) were measured using immunoassay; free testosterone was calculated. Reference intervals (central 95%) were calculated according to Clinical Laboratory Standards Institute guidelines. Results: When evaluating general endocrine laboratory tests in people using masculinizing hormones, reference intervals for cisgender men can be applied for total and free testosterone and SHBG and reference intervals for cisgender women can be applied for prolactin. Reference intervals for estradiol, LH, FSH, AMH, and DHEAS differ from those used for cisgender men and cisgender women, and therefore should be interpreted using intervals specific to the transmasculine population. For testosterone and estradiol, results from immunoassays were clinically equivalent to mass spectrometry. Conclusion: Masculinizing hormones will alter the concentrations of commonly evaluated endocrine hormones. Providers and laboratories should use appropriate reference intervals to interpret the results of these tests.
机译：背景:Gender-affirming疗法睾丸激素是常用的援助男性化的变性人。通常测量浓度,但是解读的结果将是很困难的缺乏出版的参考区间。方法:健康的变性人被规定的睾酮(n = 82)至少一年是从内部招募专业的医学和初级保健诊所变性人的医疗保健。并使用免疫测定和雌二醇测定质谱;孕激素,她们血液中的抗苗勒氏管激素(抗苗勒氏管激素),硫酸脱氢表雄酮(DHEAS)用免疫测定;计算。根据临床实验室计算标准协会的指导方针。评估一般内分泌实验室测试人们使用雄性激素,参考间隔cisgender男人可以申请总游离睾酮和SHBG参考区间cisgender女人可以申请了催乳素。那些用于cisgender男性和cisgender女性,因此应该被使用间隔特定transmasculine人口。免疫测定的临床结果相当于质谱。雄性激素会改变的浓度通常评估内分泌荷尔蒙。适当的参考区间来解释这些测试的结果。

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