Grossly Elevated False-Positive High-Sensitivity Troponin I Due to Heterophilic Antimouse IgG1 Antibodies

John G. Lewis; Christopher M. Florkowski

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Grossly Elevated False-Positive High-Sensitivity Troponin I Due to Heterophilic Antimouse IgG1 Antibodies

机译：严重升高假阳性高灵敏度由于异染的肌钙蛋白I Antimouse IgG1抗体

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Although highly sensitive assays for the cardiac tropo-nins are now considered the optimal biomarkers for the diagnosis of acute myocardial infarction, it is becoming increasingly apparent that there may be discordance between the 2 most common troponin markers. In the absence of myocardial injury, this poses a diagnostic problem for the laboratory and an even greater diagnostic clinical problem. Strategies are needed to rule out analytically false results. These may include dilution, treatment with blocking agents, precipitation, immunoglobulin removal, or gel filtration (1-4).

机译：虽然心脏高度敏感的化验tropo-nins现在被认为是最优的生物标志物的诊断急性心肌梗塞,它正变得越来越明显可能有2大部分之间的不和谐常见的肌钙蛋白标记。心肌损伤,这构成了诊断实验室和一个更大的问题诊断的临床问题。需要排除分析错误的结果。这些可能包括稀释,治疗阻断剂、降水、免疫球蛋白移除或凝胶过滤(1 - 4)。

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来源
《The journal of applied laboratory medicine.》 |2020年第4期|815-817|共3页
作者
John G. Lewis; Christopher M. Florkowski;
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作者单位

Endocrinology and Steroid Laboratory, Canterbury Health Laboratories, Christchurch, New Zealand;

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原文格式 PDF
正文语种英语
中图分类诊断学;
关键词
Acute Myocardial Infarction; Laboratories; Troponin IHIGH SENSITIVITYGel ChromatographyIgG1BLOCKING AGENT;

机译：急性心肌梗死;实验室;肌钙蛋白 IHIGH SENSITIVITYGel 色谱法 IgG1 封闭剂;

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3. Performance of a Revised Cardiac Troponin Method That Minimizes Interferences from Heterophilic Antibodies [J] . Atef Hanna, Delores M. Kaminski, François BraconnierGeorge S. CembrowskiJames F. Pierson-PerryKarl G. HockMario PlebaniMartina ZaninottoMartine MesguichMitchell G. ScottOmar F. LaterzaRégine ZimmermannWesley J. Kim Clinical Chemistry . 2002,第7期

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机译：False Increase of Cardiac Troponin I with Heterophilic Antibodies
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Grossly Elevated False-Positive High-Sensitivity Troponin I Due to Heterophilic Antimouse IgG1 Antibodies

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