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首页> 外文期刊>The journal of applied laboratory medicine. >A Multicenter Evaluation of a Nongel Mechanical Separator Plasma Blood Collection Tube for Testing of Selected Therapeutic Drugs
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A Multicenter Evaluation of a Nongel Mechanical Separator Plasma Blood Collection Tube for Testing of Selected Therapeutic Drugs

机译：一个多中心的评估Nongel机械分离器等离子血液收集管测试选择的治疗药物

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Background: Some therapeutic drugs are unstable during sample storage in gel tubes. BD VacutainerV BarricorTM Plasma Blood Collection Tube with nongel separator was compared with plasma gel tubes, BD Vacutainer PSTTM, PST II, and BD Vacutainer Serum Tube for acetaminophen, salicylate, digoxin, carbamazepine, phenytoin, valproic acid, and vancomycin during sample storage for up to 7 days.Methods: Seven hospital sites enrolled 705 participants who were taking at least one selected drug. The study tubes were collected and tested at initial time (0h), after 48h of storage at room temperature and on day 7 (after additional 5 days of refrigerated storage). The performance of BD Barricor tube was evaluated for each drug by comparing BD Barricor samples with samples from the other tubes at 0 h from the same participant; stability was evaluated by comparing test results from the same tube at 0h, 48 h, and 7 days.Results: At 0h, BD Barricor showed clinically equivalent results for selected therapeutic drugs compared with the other tubes, except phenytoin in BD PST. Phenytoin samples >20|ig/mL in BD PST had 10-12% lower values than samples in BD Barricor. During sample storage, all selected drugs remained stable for 7 days in BD Barricor and in serum aliquots. In BD PST, all drugs remained stable except phenytoin and carbamazepine and in BD PST II except for phenytoin.Conclusion: The BD Barricor Tube is effective for the collection and storage of plasma blood samples for therapeutic drug monitoring without sample aliquoting.
机译：背景:一些治疗药物是不稳定的在凝胶样品存储管。VacutainerV BarricorTM等离子采血与nongel分离器与管等离子体凝胶管,BD真空采血管PSTTM PST二世,对乙酰氨基酚和BD真空采血管血清管,水杨酸、地高辛、卡马西平、苯妥英丙戊酸、万古霉素在样本存储7天。网站招收了705名参与者至少一个所选药物。收集和测试(0 h),最初的时候48 h(存储在室温和7天(额外的5天后冷藏存储)。为每个药物通过比较BD Barricor评估样品与其他样本管在0 h从相同的参与者;评估通过比较测试结果相同管在0 h, 48小时和7天。Barricor显示临床等效的结果选择治疗药物相比其他管,除了BD苯妥英PST。苯妥英> 20 | ig /毫升样品在BD PST 10 - 12%在BD Barricor值低于样品。样本存储,所有仍然选择药物稳定在BD Barricor和7天血清整除。除了苯妥英、卡马西平和BD PST二苯妥英除外。收集和Barricor管是有效的存储的治疗性血浆的血液样本药物监测样本整除。

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