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首页> 外文期刊>The journal of applied laboratory medicine. >Anti-Domain I beta2-Glycoprotein I Antibodies and Activated Protein C Resistance Predict Thrombosis in Antiphospholipid Syndrome: TAC(I)T Study
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Anti-Domain I beta2-Glycoprotein I Antibodies and Activated Protein C Resistance Predict Thrombosis in Antiphospholipid Syndrome: TAC(I)T Study

机译：Anti-Domain我beta2-Glycoprotein抗体和活化蛋白C抵抗预测血栓形成在Antiphospholipid综合症:TAC (I)研究

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摘要

Background: Antibodies binding to domain I of b2-glycoprotein I (aDI) and activated protein C (APC) resistance are associated with an increased risk of thrombosis in cross-sectional studies. The objective of this study was to assess their predictive value for future thromboembolic events in patients with antiphospholipid antibodies (aPL) or antiphospholipid syndrome.Methods: This prospective multicenter cohort study included consecutive patients with aPL or systemic lupus er-ythematosus. We followed 137 patients (43.5 6 15.4year old; 107 women) for a mean duration of 43.1 620.7 months.Results: We detected aDI IgG antibodies by ELISA in 21 patients. An APC sensitivity ratio (APCsr) was determined using a thrombin generation-based test. The APCsr was higher in patients with anti-domain I antibodies demonstrating APC resistance (0.75 60.13 vs 0.48 60.20, P95th percentile; HR, 6.07 [95% CI, 1.69-21.87]; P = 0.006). A sensitivity analysis showed an increased risk of higher aDI IgG levels up to HR 5.61 (95% CI, 1.93-16.31; P = 0.01). In multivariate analysis, aDI IgG (HR,3.90 [95% CI, 1.33-11.46]; P = 0.01) and APC resistance (HR,4.98 [95% CI, 1.36-18.28]; P = 0.02) remained significant predictors of thrombosis over time.
机译：背景:抗体绑定到域的我b2-glycoprotein我(aDI)和活化蛋白C(APC)阻力增加横断面研究中血栓形成的风险。本研究的目的是评估他们为未来的血栓栓塞事件的预测价值患者antiphospholipid抗体(aPL)或antiphospholipid综合症。前瞻性多中心队列研究包括在内连续aPL患者或系统性红斑狼疮er-ythematosus。15.4岁;43.1 - 620.7个月。抗体的ELISA 21个病人。灵敏度比(APCsr)决心使用凝血酶生成的测试。高患者anti-domain我抗体展示APC阻力(0.75 60.13 vs 0.4860.20, P 95;(95% CI, 1.69 - -21.87);分析显示更高的aDI的风险增加免疫球蛋白水平人力资源5.61 (95% CI, 1.93 - -16.31;0.01)。(95% CI, 1.33 - -11.46);阻力(HR 4.98 (95% CI, 1.36 - -18.28);0.02)保持的重要预测因子随着时间的推移血栓形成。

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