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Antipsychotic drug use: McLean Hospital, 2002.

机译：抗精神病药物使用:麦克莱恩医院,2002年。

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OBJECTIVE: Major changes in antipsychotic treatment in recent years encouraged a survey of inpatient practice in 2002, compared with earlier samples. METHODS: Based on records of a random sample of McLean Hospital inpatients prescribed antipsychotics in 2002, the study recorded DSM-IV discharge diagnosis, all psychotropic treatments and doses, initial, peak and final doses of all antipsychotics, clinical status at admission and discharge, and adverse effects reported. Results were compared with similar data from our earlier surveys. RESULTS: Subjects were 344 inpatients (n = 202 women, 59%), diagnosed with psychotic (n = 102, 30%), bipolar (n = 93, 27%), major depressive (n = 67, 19.5%), dementia (n = 19, 5.5%), substance-use (n = 28, 8%) or other psychiatric disorders (n = 35, 10%). Second-generation antipsychotics accounted for 88% of antipsychotic prescriptions; 17% of patients received > or = 2 antipsychotics and total CPZ-eq discharge does in 2002 averaged 291 +/- 305 mg/day (22% less than a 1998 peak). Doses were unrelated to age, but higher in men, among psychotic vs major affective disorder patients, and with greater illness-severity and longer hospitalization. There was a 3.3-fold increase in the simultaneous use of > or = 3 psychotropic agents since 1998. CONCLUSIONS: The use of second-generation antipsychotics dominates current inpatient practice. Total antipsychotic dosing has not increased recently, but the use of multiple psychotropics increased strikingly from 1998 to 2002.
机译：摘要目的:抗精神病的主要变化治疗近年来鼓励的调查2002年住院病人练习,而早些时候样本。麦克莱恩医院住院病人样本规定2002年抗精神病药物,研究记录了dsm - iv出院诊断,所有精神治疗,初始剂量最高和最终的剂量在入学和抗精神病药物,临床状态放电,不良反应报道。与类似的数据从我们的同期相比吗调查。= 202名女性,59%),诊断出患有精神病(n =102年,30%)、双(n = 93, 27%),专业抑郁(n = 67, 19.5%)、痴呆(n = 19日5.5%),物质使用(n = 28日8%)或其他精神疾病(n = 35岁,10%)。第二代抗精神病药物占抗精神病药物处方的88%;患者接受> = 2抗精神病药物和总CPZ-eq放电2002年平均为291年+ / - 305毫克/天(比1998年的峰值下降了22%)。与年龄无关,但更高的男性,在吗精神病与主要情感障碍病人,和更大的illness-severity和更长时间住院治疗。同时使用> = 3精神自1998年以来代理。第二代抗精神病药物占主导地位当前的住院病人的实践。最近剂量并没有增加,但使用多个抗明显增加1998年到2002年。

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