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Onset of antidepressant action: a pharmacological question?

机译：出现抗抑郁作用:药理问题吗?

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OBJECTIVE: This study was conducted to analyse the onset of action of antidepressants in naturalistic conditions. METHOD: Multicenter, prospective, open-label, non-comparative naturalistic study among 582 depressed outpatients treated with mirtazapine. The patients were assessed at screening, and after 1, 2 and 4 weeks by the 17-item Hamilton depression rating scale (17-HAM-D) and clinical global impression (CGI). Onset of action was measured by traditional analyses based on the time to a persistent reduction of more than 50% from baseline on the 17-HAM-D. Patients were grouped into four groups: very fast responders, fast responders, traditional responders and partial or non-responders. The non-parametric Kruskall-Wallis test was used to assess differences between the groups and logistic regression to predict response after 1 week of treatment. RESULTS: 16% of patients had a very fast response, 42.1% a fast response, 26.5% a traditional response and 15.5% a partial or non-response. There were no significant differences between these groups with regard to dose of mirtazapine or sociodemographic characteristics. The baseline total 17-HAM-D was lower in the faster groups than in the slower groups. The evolution of 17-HAM-D items was similar in each responder group. CONCLUSION: Time to response varied from early faster response to late slower response. The evolution of 17-HAM-D for each type of response was similar, but occurred at a different time in each group. Copyright (c) 2005 John Wiley & Sons, Ltd.
机译：摘要目的:本研究进行了分析开始行动的抗抑郁药自然条件。潜在的、非盲、non-comparative自然的研究在582年抑郁门诊病人和米氮平治疗。患者在筛选、评估1之后,2和4周的汉密尔顿抑郁测量表评定量表(17-HAM-D)和临床全球印象(CGI)。传统的基于时间的分析持续减少超过50%17-HAM-D基线。分成四组:快速反应、快速急救员,传统反应和部分或无。Kruskall-Wallis测试是用来评估组织和物流之间的差异回归预测响应后1周治疗。快速响应、快速响应的42.1%,26.5%传统反应和部分或15.5%情况说明。这些团体之间的差异有关剂量的米氮平或社会人口特征。更快的组低于慢组。类似于每个应答器组。从早期更快的响应响应不同后期反应慢。为每种类型的反应是相似的,但是发生在不同的时间在每一个组。版权(c) 2005年约翰·威利& Sons有限公司

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