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首页> 外文期刊>Human psychopharmacology: clinical and experimental >IL-6 levels decrease with SSRI treatment in patients with major depression.
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IL-6 levels decrease with SSRI treatment in patients with major depression.

机译：il - 6水平降低与SSRI治疗抑郁症患者。

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OBJECTIVE: Some evidence indicates that an immune response with an increased production of proinflammatory cytokines often accompanies major depression. The objective of this study was to examine the serum levels of IL-6 in patients with major depression and the changes occurring in IL-6 levels during treatment with selective serotonin reuptake inhibitors (SSRI). METHOD: Twenty-three patients with a DSM-IV diagnosis of major depressive disorder and 23 healthy matched controls were included in the study. The severity of depression was measured with the Hamilton rating scale for depression. Blood samples for IL-6 levels were obtained at baseline and at week 6 of treatment and IL-6 concentrations were evaluated using a solid phase sandwich enzyme immunoassay. All patients were treated with an SSRI. RESULTS: The IL-6 levels showed no statistically significant difference between the patients and the controls at baseline. However, IL-6 levels after treatment with SSRIs were significantly lower compared with the baseline IL-6 levels of both the patients and the controls. CONCLUSION: The results of this study suggest that proinflammatory cytokines show some changes during the course of treatment of major depression. These findings might also be considered as supporting the hypothesis of a modulatory role of antidepressants on the immune system. Copyright (c) 2005 John Wiley & Sons, Ltd.
机译：摘要目的:一些证据表明免疫响应的增加产量促炎细胞因子通常伴随着专业抑郁症。检查患者的血清il - 6水平重性抑郁症和发生的变化il - 6水平与选择性治疗期间5 -羟色胺再摄取抑制剂(SSRI)。23 dsm - iv诊断的患者重度抑郁症和23个健康的匹配控制包括在这项研究。用汉密尔顿抑郁的测量抑郁评定量表。获得基线和il - 6水平6治疗和il - 6的浓度评估使用固相酶三明治免疫测定。五羟色胺再摄取抑制剂。显著统计学差异病人和控制基线。il - 6水平与ssri类药物治疗后与基线相比显著降低的病人和il - 6水平控制。表明,促炎细胞因子表现出一些治疗过程中主要的变化抑郁症。认为是支持的假设抗抑郁药物的免疫调节作用系统。有限公司

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