• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Human psychopharmacology: clinical and experimental >Seasonal variations in ((3)H)citalopram platelet binding between healthy controls and violent offenders in Finland.
【24h】

Seasonal variations in ((3)H)citalopram platelet binding between healthy controls and violent offenders in Finland.

机译：季节性的变化((3)H)西酞普兰血小板健康对照组和暴力之间的绑定关系罪犯在芬兰。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Monthly binding densities (B(max)) of [(3)H]citalopram to the platelet serotonin transporter (SERT) was measured longitudinally over 1 year in a control group of 18 healthy Finnish male volunteers. Single platelet samples were also analysed from 33 men who were incarcerated for violent crimes during the same calendar year. A statistically significant seasonal variation in SERT B(max) was observed in both data sets, and bi-monthly floating averages for SERT B(max) were calculated and then fit to an annual sinusoidal curve for both groups. The B(max) for platelet [(3)H]citalopram binding showed a statistically significant (p = 0.001) seasonal variance between a winter (January-February) maximum of 1590 fmol/mg protein and a summer (July-August) minimum of 1216 fmol/mg protein for the control group, with an R(2) of 70% for the annual sinusoidal curve fit. A statistically significant (p = 0.007) seasonal variance was also observed between a winter (January-February) maximum of 1980 fmol/mg protein and an autumnal (August-September) minimum of 1234 fmol/mg protein for the violent offenders, again with an R(2) of 70% for the annual sinusoidal curve fit. This observation lends additional support to the idea that violent human behavior and impulsivity may be directly linked to values of SERT B(max), which can be affected by various psychoactive drugs and also varies with the natural change of seasons. Copyright (c) 2005 John Wiley & Sons, Ltd.
机译：每月绑定的密度(B (max))[(3) H]西酞普兰血小板5 -羟色胺转运体(泽特)是测量纵向在1年的对照组18健康芬兰男性志愿者。还分析了从33人被监禁期间为暴力犯罪一样日历年。季节性变化在泽特B (max)被观察到两个数据集,双月漂浮的平均水平泽特B (max)计算然后适合一年一度的两组正弦曲线。B (max)血小板[(3)H]西酞普兰绑定显示统计学意义(p = 0.001)季节性差异之间的冬天(第二年)1590 fmol /毫克蛋白质和夏季(7)最低为对照组,1216 fmol /毫克蛋白R(2) 70%的年度正弦曲线健康。季节之间的方差也观察到冬天(第二年)1980 fmol /毫克蛋白质和一个秋天(August-September)最低1234 fmol /毫克蛋白的暴力罪犯,再一次的R(2)为70%一年一度的正弦曲线拟合。提供额外的支持,暴力人类行为和冲动可能直接泽特B (max)的值,可以受到各种精神药物和也随季节的自然变化。版权(c) 2005年约翰·威利& Sons有限公司

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号