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首页> 外文期刊>Human psychopharmacology: clinical and experimental >Double-blind comparative study of the action of repeated administration of milnacipran versus placebo on cognitive functions in healthy volunteers.
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Double-blind comparative study of the action of repeated administration of milnacipran versus placebo on cognitive functions in healthy volunteers.

机译：双盲比较研究的作用重复milnacipran与管理安慰剂在健康的认知功能志愿者。

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OBJECTIVE: The principal objective was to compare the effects of milnacipran, an antidepressant characterized by a dual-action on serotonin and noradrenaline reuptake, with placebo on memory, attention and psychomotor performance in healthy volunteers. The secondary objective was to evaluate the effects of milnacipran on mood, anxiety and vigilance in these subjects. METHODS: In a double-blind crossover randomized trial, milnacipran (50 mg b.d.) or placebo was administered during two periods of 7 days separated by a washout period of 7 days. Memory tests (recall of words, images and coloured bars), tests to evaluate attention and vigilance (squares test, critical flicker fusion test and choice reaction time test) and visual analogue scales for affect and sleep were used. RESULTS: There were no significant differences between milnacipran and placebo groups with respect to the psychomotor functions tested. No differences were observed in the Norris scales for vigilance, anxiety or satisfaction or in the sleep questionnaire (sleep latency, sleep quality and waking). CONCLUSION: Milnacipran, administered at 100 mg per day for 7 days to healthy volunteers, had no effects on cognitive functions.
机译：目的:主要目的是比较milnacipran的影响,抗抑郁药物特点是对5 -羟色胺和双重作用去甲肾上腺素的再摄取,安慰剂的记忆,注意力和精神运动在健康的表现志愿者。评估milnacipran对情绪的影响,这些科目的焦虑和警惕。在一个双盲交叉随机试验,milnacipran(50毫克b.d。)或安慰剂管理两个时期的7天分离的洗脱期7天。测试(回忆的话,图片和颜色酒吧),测试评估的关注和警惕(广场测试,测试和临界闪烁融合选择反应时测试)和视觉模拟尺度的影响和睡眠。没有显著的差异关于milnacipran和安慰剂组精神运动功能测试。观察诺里斯尺度的警惕,焦虑或满意或睡眠调查问卷(睡眠潜伏期、睡眠质量醒着)。7天100毫克每天健康的志愿者,没有对认知功能的影响。

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