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首页> 外文期刊>Human psychopharmacology: clinical and experimental >A randomized clinical trial comparing doses and efficacy of lormetazepam tablets or oral solution for insomnia in a general practice setting.
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A randomized clinical trial comparing doses and efficacy of lormetazepam tablets or oral solution for insomnia in a general practice setting.

机译：一个随机临床试验比较和剂量lormetazepam平板电脑或口头解决方案的有效性失眠的一个惯例。

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摘要

Lormetazepam is a short-acting benzodiazepine hypnotic which is beneficial in shortening the time to onset of sleep. The aim of the study was to assess a new formulation of lormetazepam (oral solution) in comparison with lormetazepam tablets in out-patients with insomnia. This trial was an open randomized parallel group study conducted by 30 general practitioners. One hundred and eight patients took 0.5 mg on the first night and were allowed to increase their dosage by 0.25 mg (for oral solution) and 0.5 mg (for tablets), respectively, each day and every 2 days. The patients assessed the efficacy, acceptability and tolerance of lormetazepam using a diary card and a set of visual analogue scales assessing their sleep. Over 14 days of treatment, the mean daily dose of lormetazepam was lower in the oral solution group than in the tablets group (0.78 mg versus 0.97 mg). The cumulated dose of lormetazepam was lower with the oral solution (18% reduction). No significant difference between the two groups was found in the assessment of sleep characteristics. The occurrence of side effects did not differ between the two groups. These results suggest that a unitary dose as achieved by an oral solution of lormetazepam allows easier determination of the minimal individual effective dose.
机译：Lormetazepam短效苯二氮有利于缩短催眠发病时间的睡眠。评估的新配方lormetazepam(口服解决方案)与lormetazepam相比平板电脑在门诊失眠。打开随机平行组研究30全科医生。病人在第一天晚上0.5毫克,允许由0.25毫克(增加剂量口服溶液)和0.5毫克(平板电脑),分别每一天和每2天。病人评估疗效,可接受性使用日记卡和lormetazepam公差一组视觉模拟量表评估他们睡眠。在口服剂量的lormetazepam较低解决方案组比平板电脑组(0.78毫克和0.97毫克)。与口服溶液lormetazepam较低(减少18%)。两组之间被发现的评估睡眠的特点。发生的副作用没有差异两组。单一剂量通过口服溶液lormetazepam允许容易确定的最小的个人有效剂量。

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