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首页> 外文期刊>Human psychopharmacology: clinical and experimental >Maintenance treatment for schizophrenia with quetiapine.
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Maintenance treatment for schizophrenia with quetiapine.

机译：维持治疗的精神分裂症喹硫平。

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With the majority of current information being derived from short-term clinical trials, the impact of atypical antipsychotics during maintenance treatment of schizophrenia is of considerable interest, although only limited data are available at present. The present report is an analysis of data that are available up to 156 weeks after the start of an open-label extension (OLE) phase of three, double-blind randomized trials in quetiapine-treated patients who responded to an initial 6-week treatment period. The mean daily quetiapine dose (range 150-750 mg) was 439.5 mg for patients included in the brief psychiatric rating scale (BPRS) and 438.5 mg for patients included in the clinical global impression (CGI) analyses. The initial mean acute phase BPRS total score (40.67; n=258) and CGI severity of illness score (4.81; n=259) were reduced at the start of the OLE to 13.94 and 3.00, respectively. After 156 weeks, endpoint scores were 9.04 for BPRS and 2.43 for CGI severity of illness. Although limited by patient attrition, these OLE data suggest that an initial beneficial response with quetiapine treatment can be maintained over a long-term period.
机译：与大多数当前的信息来自短期临床试验在非典型抗精神病药物的影响维持治疗的精神分裂症相当大的兴趣,尽管只有有限的数据目前可用。分析的数据可高达156几周后一个开放式扩展的开始(OLE)三个阶段,双盲随机试验quetiapine-treated病人回应一个初始六周治疗期。平均每日剂量喹硫平(范围150 - 750毫克)439.5 mg病人包括在短暂精神病评定量表(BPRS)和438.5毫克患者中临床全球印象(CGI)分析。阶段BPRS总分(40.67;疾病严重程度评分(4.81;减少在13.94和OLE的开始3.00,分别。分数9.04 2.43 BPRS和CGI疾病的严重程度。摩擦,这些OLE数据表明一个初始有益与喹硫平治疗的反应保持在一个长期的时期。

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