Drug induced encephalopathy in six epileptic patients: topiramate? valproate? or both?

Latour P; Biraben A; Polard EBentue Ferrer DBeauplet ATribut OAllain H

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Drug induced encephalopathy in six epileptic patients: topiramate? valproate? or both?

机译：在六个癫痫药物诱发脑病病人:托吡酯?

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Six severe epileptic patients developed stuporous encephalopathy with marked cognitive impairment when topiramate (TPM) and sodium valproate (VPA) were coprescribed for five patients, and when monotherapy with TPM was introduced for one patient. In four patients, ammonaemia increased and then returned to normal after TPM or VPA withdrawal. This severe potential side effect must be recognized. Moreover two distinct mechanisms might explain this toxicity: (1). a pharmacokinetic interaction between VPA and TPM, leading to hyperammonaemia, (2). a pharmacodynamic mechanism due to a direct toxicity of TPM in at-risk epileptic patients.

机译：六个严重癫痫患者昏迷的开发脑病与认知障碍当托吡酯(TPM)和钠丙戊酸钠(VPA)coprescribed 5例,当单介绍了TPM病人。然后TPM或VPA后恢复正常撤军。必须承认。机制可以解释这毒性:(1)一个药代动力学相互作用VPA TPM,导致hyperammonaemia,(2)一个由于直接的药效学机制毒性的TPM高危癫痫患者。

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来源
《Human psychopharmacology: clinical and experimental》 |2004年第3期|193-203|共11页
作者
Latour P; Biraben A; Polard EBentue Ferrer DBeauplet ATribut OAllain H;
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作者单位

Department of Neurology, Hospital Cavale Blanche, Boulevard Tanguy Prigent, 29200 Brest, France.;

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原文格式 PDF
正文语种英语
中图分类药学;
关键词
Valproate; Fructose; Neurotoxicity SyndromesEpilepsyValproic AcidAnticonvulsantsEncephalopathytopiramate;

机译：丙戊酸丙戊酸酯;果糖;神经毒性综合征癫痫丙戊酸抗惊厥药脑病托吡酯;

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Drug induced encephalopathy in six epileptic patients: topiramate? valproate? or both?

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