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首页> 外文期刊>Human psychopharmacology: clinical and experimental >A preliminary study of the comparative effects of olanzapine and risperidone on cognition in schizophrenia.
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A preliminary study of the comparative effects of olanzapine and risperidone on cognition in schizophrenia.

机译：比较的影响的初步研究奥氮平和利培酮对认知精神分裂症。

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摘要

The aim of this study was to compare the effects of olanzapine and risperidone on cognitive functions in patients with schizophrenia. The subjects were schizophrenic outpatients, all meeting DSM-IV diagnostic criteria for schizophrenia and already treated with risperidone. In the experimental group (15), risperidone was changed to olanzapine to be administered for 8 weeks. Risperidone was maintained without a change in the daily dose in the control group (13). The assessment of clinical symptoms and cognitive functions in both groups was made at baseline and at 8 weeks. The experimental group relative to the control group showed significant improvement in five items such as immediate and delayed recall of verbal memory, verbal fluency, visual memory and total error of executive function. Although these data are preliminary, they could suggest the possibility of cognitive benefits from treatment with olanzapine relative to risperidone. These findings did not appear to be mediated by changes in clinical symptoms and side effects.
机译：本研究的目的是比较的影响奥氮平与利培酮对认知精神分裂症患者的功能。受试者精神分裂症门诊病人,所有会议dsm - iv诊断标准精神分裂症和已经处理利培酮。利培酮是改变了奥氮平管理8周。保持每日剂量的变化对照组(13)。临床症状和认知功能组在基线和8周。实验组与对照组五等都有了明显的改善作为非文字记忆的直接和延迟回忆,语言流畅,视觉记忆和总误差执行功能。初步的,他们可以建议的可能性的认知从治疗中获益奥氮平与利培酮。发现似乎并未由变化在临床症状和副作用。

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