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首页> 外文期刊>Human psychopharmacology: clinical and experimental >Effects of modafinil on cognitive and meta-cognitive performance.
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Effects of modafinil on cognitive and meta-cognitive performance.

机译：莫达非尼对认知的影响元认知的性能。

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The stimulant modafinil has proved to be an effective treatment modality for narcolepsy and related sleep disorders and is also being studied for use during sustained military operations to ameliorate the effects of fatigue due to sleep loss. However, a previous study reported that a relatively large, single dose of modafinil (300 mg), administered to already sleep-deprived individuals, caused participants to overestimate their cognitive abilities (i.e. 'overconfidence'). Because the predominant application of modafinil is in otherwise healthy, non-sleep-deprived individuals, the present study investigated the generality of modafinil-induced overconfidence in a group of 18 healthy, non sleep-deprived adults. The design involved a double-blind, placebo controlled, fully within-subjects manipulation of placebo and modafinil (4 mg/kg: approximately 300 mg, on average) over three 50-min cognitive testing sessions (i.e. before drug ingestion, and at 90 and 180 min after drug ingestion). The cognitive task battery included subjective assessments of mood, fatigue, affect, vigor and motivation, and cognitive assessments of serial reaction time, logical reasoning, visual comparison, mental addition and vigilance. In addition, trial-by-trial confidence judgements were obtained for two of the cognitive tasks and more global, task level assessments of performance were obtained for four of the cognitive tasks. Relative to placebo, modafinil improved fatigue levels, motivation, reaction time and vigilance. In terms of self-assessments of cognitive performance, both the placebo and modafinil conditions were 'well calibrated' on trial-by-trial confidence judgements, showing neither marked over- nor under-confidence. Of note, the modafinil condition displayed a non-significant tendency towards 'overconfidence' for task-level assessments of performance. The present findings highlight the need for continued research on the many complex interactions involving fatigue states, occasional versus long-term stimulant use, and subjective assessments of fatigue and cognitive performance.
机译：兴奋剂莫达非尼已被证明是一个有效治疗嗜睡症和形态相关的睡眠障碍和也正在研究在持续的军事行动来使用由于睡眠改善疲劳的影响的损失。相对较大,单一剂量的莫达非尼(300毫克),管理已经睡眠不足个人,使参与者高估他们的认知能力(即。“过度自信”)。莫达非尼的应用在健康,non-sleep-deprived个人,目前的研究调查modafinil-induced的普遍性过度自信在一群18健康、非成年人睡眠不足。双盲,安慰剂对照,充分受试的操纵安慰剂莫达非尼(4毫克/公斤:约300毫克在三第50分钟平均值)认知测试会话(即药物摄入之前,在90年和药物摄入后180分钟)。电池包括主观评估的任务情绪、疲劳、影响、活力和动力认知评估的连环反应时间,逻辑推理,视觉比较,精神加法和警惕。trial-by-trial信心判断是获得的两个认知任务等等全球、任务评估的性能水平得到了四个认知任务。相对于安慰剂,莫达非尼改善疲劳水平、动机、反应时间和警惕。自我评价的认知性能,安慰剂和莫达非尼条件是“校准”trial-by-trial信心判断,显示既不明显,也不缺乏自信。注意,莫达非尼条件显示非重大的倾向“过度自信”性能的任务级别的评估。现在发现强调持续的必要性研究许多复杂的相互作用涉及疲劳状态,偶尔与长期使用兴奋剂,主观的评估的疲劳和认知能力。

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