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首页> 外文期刊>Human psychopharmacology: clinical and experimental >Effects of acute cortisol and cocaine administration on attention, recall and recognition task performance in individuals with cocaine dependence.
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Effects of acute cortisol and cocaine administration on attention, recall and recognition task performance in individuals with cocaine dependence.

机译：急性皮质醇和可卡因的影响政府的注意力,回忆和识别任务在个人的表现可卡因依赖。

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摘要

This study investigated the effects of acute cocaine administration on cognition, and whether these can be modeled using exogenous hydrocortisone, because cocaine-induced cortisol elevations may influence its cognitive effects. Twelve cocaine-dependent individuals received an intravenous bolus of cortisol (0.5 or 0.2 mg/kg) and cocaine (0.2 mg/kg) in a double-blind randomized placebo-controlled and counterbalanced fashion. Cognitive testing included verbal tasks of vigilance attention, free recall and recognition memory before the boluses and at 20, 60 and 100 min thereafter. The statistical analysis investigated dose response effects while accounting for all sources of variance in the design. No effects of low dose cocaine were found on any variables. Low dose cortisol enhanced and high dose impaired vigilance attention, and a trend was found for the same dose response profile on twice-heard words. An opposite trend, inconsistent with prior research on cortisol and cognition, was observed for recognition: low dose impaired and high dose enhanced recognition of once-heard words, and a very weak trend was found for recognition of new words. These findings, though tempered by design limitations, suggest a complex non-linear cortisol attention/recognition dose-response relationship and call for further research to elucidate cortisol's effects on cognition and their role in the pathophysiology of cocaine dependence. Copyright 2004 John Wiley & Sons, Ltd.
机译：本研究调查的影响严重可卡因管理认知,是否这些可以使用外源性建模氢化可的松,因为cocaine-induced皮质醇海拔可能影响其认知效果。十二cocaine-dependent个人收到了静脉注射丸的皮质醇(0.5或0.2毫克/公斤)和可卡因(0.2毫克/公斤)在一个双盲随机安慰剂对照和平衡时尚。警惕关注,自由回忆和识别内存丸之前和在20岁的时候,60 - 100分钟。分析研究了剂量反应的影响占所有来源的方差设计。在任何变量。高剂量受损警惕关注,趋势被发现同样的剂量反应在twice-heard的话。与之前研究皮质醇和不一致观察认知、认可:低剂量和高剂量增强识别受损曾听到单词,并且发现了一个非常弱的趋势新单词的识别。尽管受到设计的局限性,建议复杂的非线性皮质醇/注意识别剂量反应关系,进一步要求的研究来阐明皮质醇的影响认知及其在病理生理学中的作用可卡因依赖。和儿子,有限公司

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