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首页> 外文期刊>Human psychopharmacology: clinical and experimental >Evidence for synergistic modulation of early information processing by nicotinic and muscarinic receptors in humans.
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Evidence for synergistic modulation of early information processing by nicotinic and muscarinic receptors in humans.

机译：早期的证据协同调制烟碱和信息处理毒蕈碱的受体。

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Impairments in early information processing are a hallmark feature of diverse neuropsychiatric disorders including schizophrenia and Alzheimer's disease (AD). Several lines of evidence implicate a dysfunction of the cholinergic system in these disorders, particularly in AD where there is known degeneration in major cholinergic pathways. Inspection time (IT), a measure of early visual information processing speed, has been shown to be sensitive to cholinergic manipulation. The current study employed the IT task to (1) examine the independent roles of nicotinic and muscarinic receptors in modulating information processing and (2) investigate the interaction of nicotinic and muscarinic receptor systems in modulating information processing. Twelve healthy participants completed a randomized, double-blind, placebo-controlled study under four drug conditions; (1) placebo, (2) mecamylamine (15 mg; oral), (3) scopolamine (0.4 mg, s.c.), (4) mecamylamine (15 mg)+scopolamine (0.4 mg). IT measures were examined at baseline and 2.5 h post drug administration. Selective blockade of nicotinic receptors with mecamylamine did not significantly impair IT, whereas selective blockade of muscarinic receptors with scopolamine produced a significant but small impairment in IT. Combined blockade of both receptor types with scopolamine and mecamylamine produced a large impairment in IT performance. The results indicate that both nicotinic and muscarinic receptors are involved in modulating IT, and that the two systems may function synergistically to modulate early visual information processing. These findings suggest that functional abnormalities in both nicotinic and muscarinic systems may underlie deficits in early visual information processing seen in disorders such as Alzheimer's disease and schizophrenia. Copyright 2004 John Wiley & Sons, Ltd.
机译：信息处理是一个障碍各种神经精神的标志特征疾病包括精神分裂症和阿尔茨海默氏症病(AD)。胆碱能系统的功能障碍哪里有障碍,尤其是在广告已知退化主要胆碱能通路。检查时间(IT),早期视觉的测量信息处理速度,已被证明是敏感的胆碱能操纵。目前的研究工作(1)检查任务独立自主的烟碱和毒蕈碱的角色受体在调制信息处理(2)调查烟碱的交互在调制和毒蕈碱的受体系统信息处理。参与者完成了一项随机,双盲,安慰剂对照研究在4药物的条件;(15毫克;(4)四甲双环庚胺(15毫克)+莨菪碱(0.4毫克)。措施在基线检查和2.5 h药品监督管理局。烟碱受体与四甲双环庚胺没有明显削弱,而选择性的封锁和莨菪碱毒蕈碱的受体产生了显著但小障碍它。莨菪碱和四甲双环庚胺大量生产损伤性能。表明,烟碱和毒蕈碱的受体参与调节,两个系统可以实现协同功能调节早期视觉信息处理。这些发现表明,功能在烟碱和毒蕈碱的异常系统可能在早期视觉基础赤字信息处理等障碍阿尔茨海默氏症和精神分裂症。2004年约翰·威利& Sons有限公司

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