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首页> 外文期刊>Human psychopharmacology: clinical and experimental >Folic acid: neurochemistry, metabolism and relationship to depression.
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Folic acid: neurochemistry, metabolism and relationship to depression.

机译：叶酸:新陈代谢和神经化学与抑郁症的关系。

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The associations of folic acid and its derivatives with depressive disorder are reviewed. Derivatives of folic acid such as biopterins and the synthesis of S-adenosyl methionine (SAM) are known either to be associated with improvement or to have a direct therapeutic effect in depressive disorder. Studies investigating plasma and red cell folic acid levels in depressed patients have used differing assay methodologies which make comparison difficult, although there is substantial evidence of the association between depressive disorder (particularly severe depression) and low folic acid levels. The few studies available suggest folic acid has either antidepressant properties or can act as an augmenting agent for standard antidepressant treatment. A recently discovered genetic variant (5,10 MTHFR) leading to altered folic acid metabolism may explain why some individuals are vulnerable to the effects of folic acid deficiency, despite adequate intake. The links of 5,10 MTHFR to the presence of depressive disorder in the community are being investigated. Copyright 2004 John Wiley & Sons, Ltd.
机译：叶酸及其衍生物的关联抑郁障碍患者进行了综述。衍生品的叶酸,如生物蝶呤和S-adenosyl的合成甲硫氨酸(SAM)与改进或在抑郁有直接治疗效果障碍。抑郁症患者的细胞叶酸水平使用不同的分析方法使比较困难,虽然有大量的证据之间的关系抑郁症(尤其严重抑郁症)和低叶酸水平。研究显示叶酸已可用抗抑郁药或可以作为一个属性增加代理标准的抗抑郁药治疗。(5, 10 MTHFR)导致改变叶酸代谢可以解释为什么有些人易受影响的叶酸缺乏,尽管足够的摄入量。5、10 MTHFR抑郁症的存在在社区正在接受调查。版权2004年约翰·威利& Sons有限公司

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