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首页> 外文期刊>Human psychopharmacology: clinical and experimental >The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans.
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The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans.

机译：茶氨酸的急性效应相比阿普唑仑在人类预期的焦虑。

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L-Theanine (delta-glutamylethylamide) is one of the predominant amino acids ordinarily found in green tea, and historically has been used as a relaxing agent. The current study examined the acute effects of L-theanine in comparison with a standard benzodiazepine anxiolytic, alprazolam and placebo on behavioural measures of anxiety in healthy human subjects using the model of anticipatory anxiety (AA). Sixteen healthy volunteers received alprazolam (1 mg), L-theanine (200 mg) or placebo in a double-blind placebo-controlled repeated measures design. The acute effects of alprazolam and L-theanine were assessed under a relaxed and experimentally induced anxiety condition. Subjective self-reports of anxiety including BAI, VAMS, STAI state anxiety, were obtained during both task conditions at pre- and post-drug administrations. The results showed some evidence for relaxing effects of L-theanine during the baseline condition on the tranquil-troubled subscale of the VAMS. Alprazolam did not exert any anxiolytic effects in comparison with the placebo on any of the measures during the relaxed state. Neither L-theanine nor alprazalam had any significant anxiolytic effects during the experimentally induced anxiety state. The findings suggest that while L-theanine may have some relaxing effects under resting conditions, neither L-theanine not alprazolam demonstrate any acute anxiolytic effects under conditions of increased anxiety in the AA model. Copyright 2004 John Wiley & Sons, Ltd.
机译：茶氨酸(delta-glutamylethylamide)就是其中之一主要氨基酸通常发现的绿茶,历史上被用作放松的代理。茶氨酸在比较严重的影响标准的苯二氮卓类药物抗焦虑药,阿普唑仑和安慰剂的焦虑行为的措施健康的人体使用的模型预期焦虑(AA)。志愿者接受了阿普唑仑(1毫克),l -茶氨酸(200毫克)或在一个双盲安慰剂安慰剂对照重复测量设计。阿普唑仑和l -茶氨酸的严重影响在放松和实验评估诱导焦虑状态。自我报告的焦虑,包括白、VAMS污渍状态焦虑,得到在两个任务在预处理和post-drug政府条件。结果显示一些放松的证据茶氨酸的影响在基线条件的tranquil-troubled子量表VAMS。与安慰剂相比,在任何的影响这些措施在放松的状态。茶氨酸和alprazalam有任何意义抗焦虑的影响实验诱导焦虑状态。虽然茶氨酸可能有一些放松的效果在静止的条件下,无论是茶氨酸阿普唑仑展示任何急性抗焦虑药影响的条件下增加焦虑AA模型。有限公司

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