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首页> 外文期刊>Human psychopharmacology: clinical and experimental >Clinical experience with dual action antidepressants in different chronic pain syndromes.
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Clinical experience with dual action antidepressants in different chronic pain syndromes.

机译：临床经验的双重作用抗抑郁药物在不同的慢性疼痛综合症。

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A common psychopharmacology between pain and depression suggests that compounds inhibiting the reuptake of serotonin and/or noradrenaline arelikely to produce relief from chronic pain. Indeed tricyclic antidepressants have been a standard treatment of chronic pain for many years. In spiteof their improved tolerance, selective serotonin reuptake inhibitors do not appear to be particularly effective in the treatment of pain. Recently, a number of open and controlled trials with members of the new selective serotonin and noradrenaline reuptake inhibitor class of antidepressants, such as venlafaxine, milnacipran and duloxetine, suggest that these compounds may be more effective in relieving pain than selective inhibitors of serotonin reuptake. Wherever valid comparisons have been made the newer dual action drugs appear to be as effective as the tricyclics and considerably better tolerated. Dual action antidepressants are thus likely to become a widely used treatment of chronic pain both associated with andindependentof depression. Copyright 2004 John Wiley & Sons, Ltd.
机译：疼痛和之间的共同精神药理学抑郁症表明化合物抑制5 -羟色胺的再摄取和/或去甲肾上腺素可能会产生减轻慢性疼痛。事实上三环类抗抑郁药物了标准治疗的慢性疼痛年。选择性5 -羟色胺再摄取抑制剂似乎是特别有效的治疗疼痛。与新成员对照试验选择性5 -羟色胺和去甲肾上腺素再摄取抑制剂类抗抑郁药,如文拉法辛、milnacipran和度洛西汀,建议这些化合物可能更有效缓解疼痛的选择性抑制剂5 -羟色胺再摄取。已经更新的双重作用药物出现三环抗抑郁药一样有效,相当具有更好的耐受性。抗抑郁药物也可能成为一个广泛使用的治疗慢性疼痛与andindependentof抑郁有关。版权2004年约翰·威利& Sons有限公司

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